Evaluation of the Radiation Pneumonia Development Risk in Lung Cancer Cases

Yilmaz, Sercan; Adas, Yasemin Guzle; Hicsonmez, Ayse; Andrieu, Meltem Nalca; Akyurek, Serap; Gokce, Saban Cakir

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자료유형: 학술저널

저자정보: Yilmaz, Sercan (Department of Radiation Oncology, Diyarbakır State Hospital) Adas, Yasemin Guzle (Department of Radiation Oncology, Manisa State Hospital) Hicsonmez, Ayse (Department of Radiation Oncology, Medical School, Ankara University) Andrieu, Meltem Nalca (Department of Radiation Oncology, Medical School, Ankara University) Akyurek, Serap (Department of Radiation Oncology, Medical School, Ankara University) Gokce, Saban Cakir (Department of Radiation Oncology, Medical School, Ankara University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제17호

발행연도: 2014.1

수록면: 7,371 - 7,375 (5page)

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Background: Concurrent chemo-radiotherapy is the recommended standard treatment modality for patients with locally advanced lung cancer. The purpose of three-dimensional conformal radiotherapy (3DCRT) is to minimize normal tissue damage while a high dose can be delivered to the tumor. The most common dose limiting side effect of thoracic RT is radiation pneumonia (RP). In this study we evaluated the relationship between dose-volume histogram parameters and radiation pneumonitis. This study targeted prediction of the possible development of RP and evaluation of the relationship between dose-volume histogram (DVH) parameters and RP in patients undergoing 3DCRT. Materials and Methods: DVHs of 41 lung cancer patients treated with 3DCRT were evaluated with respect to the development of grade ${\geq}2$ RP by excluding gross tumor volume (GTV) and planned target volume (PTV) from total (TL) and ipsilateral (IPSI) lung volume. Results: Were admitted statistically significant for p<0.05. Conclusions: The cut-off values for V5, V13, V20, V30, V45 and the mean dose of TL-GTV; and V13, V20,V30 and the mean dose of TL-PTV were statistically significant for the development of Grade ${\geq}2$ RP. No statistically significant results related to the development of Grade ${\geq}2$ RP were observed for the ipsilateral lung and the evaluation of PTV volume. A controlled and careful evaluation of the dose-volume histograms is important to assess Grade ${\geq}2$ RP development of the lung cancer patients treated with concurrent chemo-radiotherapy. In the light of the obtained data it can be said that RP development may be avoided by the proper analysis of the dose volume histograms and the application of optimal treatment plans.

#Lung cancer #radiotherapy #radiation pneumonitis #prevention

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