Inhibitory Effects of Low-Dose Aloe-Emodin on the Development of Colorectal Tumors in Min Mice

Shimpo, Kan; Chihara, Takeshi; Kaneko, Takaaki; Beppu, Hidehiko; Wakamatsu, Kazumasa; Shinzato, Masanori; Yukitake, Jun; Sonoda, Shigeru

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자료유형: 학술저널

저자정보: Shimpo, Kan (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) Chihara, Takeshi (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) Kaneko, Takaaki (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) Beppu, Hidehiko (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University) Wakamatsu, Kazumasa (Department of Chemistry, Fujita Health University School of Health Sciences) Shinzato, Masanori (Department of Pathology, Fujita Health University School of Health Sciences) Yukitake, Jun (Department of Clinical Immunology, Fujita Health University School of Health Sciences) Sonoda, Shigeru (Division of Biochemistry, Fujita Memorial Nanakuri Institute, Fujita Health University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제14호

발행연도: 2014.1

수록면: 5,587 - 5,592 (6page)

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Aloe-emodin (AE), a natural anthraquinone compound, has been reported to exhibit anticancer activity in various cancer cell lines and anti-inflammatory effects in murine macrophages. In the present study, we investigated the cancer chemopreventive effects of AE in an Apc-deficient Min mouse model. In the first experiment, male Min mice were fed a basal diet or diets containing 5 ppm AE and 10 ppm AE for 12 weeks. The dietary administration of 5 ppm AE significantly reduced the number of colorectal tumors. In a second experiment, we investigated the effects of AE on colitis-related colon carcinogenesis in Min mouse treated with dextran sodium sulfate (DSS). Female Min mice were administered 1% DSS in their drinking water for 7 days. AE was given to mice in their diet at a dose of 5 or 50 ppm for 5 weeks. Feeding with AE significantly reduced the number of colorectal tumors. When proliferation of cells in normal-appearing colonic mucosa was assessed by monoclonal anti-rat Ki-67 antibody (MIB-5) immunohistochemistry in experiments 1 and 2, the AE treatment significantly decreased the mean MIB-5-labeling index. These results suggest that the dietary administration of low-dose AE may have chemopreventive effects against development of colorectal tumors in Min mice, possibly in part by reducing cell proliferation in colorectal mucosa.

#Aloe-emodin #colorectal tumor #Apc-deficient Min mice

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