Immune and Anti-oxidant Functions of Ethanol Extracts of Scutellaria baicalensis Georgi in Mice Bearing U14 Cervical Cancers

Peng, Yong; Guo, Cong-Shan; Li, Pan-Xia; Fu, Zhan-Zhao; Gao, Li-Ming; Di, Ya; Ju, Ya-Kun; Tian, Ru; Xue, Jia-Jia

추천

검색

자료유형: 학술저널

저자정보: Peng, Yong (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) Guo, Cong-Shan (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) Li, Pan-Xia (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) Fu, Zhan-Zhao (Department of Oncology, the First Hospital of Qinhuangdao City) Gao, Li-Ming (Department of Oncology, the First Hospital of Qinhuangdao City) Di, Ya (Department of Oncology, the First Hospital of Qinhuangdao City) Ju, Ya-Kun (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) Tian, Ru (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University) Xue, Jia-Jia (Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제10호

발행연도: 2014.1

수록면: 4,129 - 4,133 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: The objective was to study the effect of Scutellaria baicalensis Georgi ethanol extracts (SBGE) on immune and anti-oxidant function in U14 tumor-bearing mice. Materials and Methods: U14 tumor-bearing mice were randomly divided into eight groups: a control group, a cyclophosphamide (CTX) group, three dose groups of SBGEI (high, medium, low), and three dose groups of SBGEII (high, medium, low). After two weeks, the thymus and spleen weight indices of mice bearing U14 cervical cancer were calculated. Enzyme linked immunosorbent assays (ELISA) was used to determine the levels of serum IL-2, TNF-${\alpha}$, IL-8, and PCNA. MDA activity and SOD activity in plasma were measured with detection kits. Results: In the SBGE groups, thymus weight and spleen weight indices of U14 tumor-bearing mice were significantly higher than in the control group or CTX group (p<0.05). Compared to control group, the levels of serum IL-2 and TNF-${\alpha}$ in U14 tumor-bearing mice increased significantly, whereas the contents of serum IL-8 and PCNA decreased (p<0.05). The activity of SOD increased with the growing dose of SBGE, while the activity of MDA decreased significantly in the highe-rdose groups of SBGE. Conclusions: These findings suggested that SBGE, especially at high dose, 1000 mg/kg, showed significant immune and anti-oxidant effects infU14 tumor-bearing mice, which might be the mechanisms of SBGE inhibition of tumor growth.

#SBGE #U14 cervical cancer #immune #anti-oxidant #functions

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Peng, Yong

소속기관 Department of Biomedical Engineering, College of Electrical Engineering, Yanshan University