An Updated Meta-analysis Between the Association of XRCC1 Arg399Gln Polymorphism and Hepatocellular Carcinoma Risk

Zhang, Xiao-Lian; Lu, Yu; Yang, Shi; Peng, Qi-Liu; Wang, Jian; Xie, Li; Deng, Yan; He, Yu; Li, Tai-Jie; Qin, Xue; Li, Shan

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저자정보: Zhang, Xiao-Lian (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Lu, Yu (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Yang, Shi (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Peng, Qi-Liu (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Wang, Jian (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Xie, Li (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Deng, Yan (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) He, Yu (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Li, Tai-Jie (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Qin, Xue (Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University) Li, Shan (Department of Clinical Labororatory, First Affilia)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제7호

발행연도: 2014.1

수록면: 3,273 - 3,278 (6page)

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Background: Various studies have evaluated the relationship between X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism and hepatocellular carcinoma (HCC) risk, but the conclusions have been inconsistent and underpowered. The purpose of this updated meta-analysis was to examine whether XRCC1 Arg399Gln polymorphism confers susceptibility to HCC. Methods: Eligible studies extracted from PubMed, Embase, Cochrane Library, VIP (chinese) and CNKI (chinese) up to November 2013 were included in the study. Pooled odds ratio (OR) together with their 95% confidence interval (CI) were estimated to evaluate XRCC1 Arg399Gln polymorphism and HCC risk. Results: Finally, 21 studies with 4,170 cases and 5,030 controls were involved in our meta-analysis. The results demonstrated that there was significant association between Arg399Gln polymorphism and HCC risk under two contrast models in overall populations (AG vs GG: OR=1.265, 95%CI=1.036-1.545, p=0.021; AA+AG vs GG: OR=1.240, 95%CI=1.021-1.506, p=0.030). In subgroup analyses, significant association was found in Asians (A vs G: OR=1.175, 95%CI=1.013-1.362, p=0.033; AG vs GG: OR=1.317, 95%CI=1.070-1.622, p=0.009; AA+AG vs GG: OR=1.289, 95%CI=1.055-1.575, p=0.013) and Caucasians (A vs G: OR=0.591, 95%CI=0.361-0.966, p=0.036; AA+AG vs GG: OR=0.468, 95%CI=0.234-0.934, p=0.031). Conclusions: The results suggest that XRCC1 Arg399Gln polymorphism may increase HCC risk especially among Asians. However, XRCC1 Arg399Gln polymorphism might act as a protective role against HCC among Caucasians.

#XRCC1 #polymorphism #HCC #meta-analysis #risk

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Zhang, Xiao-Lian

소속기관 Department of Clinical Labororatory, First Affiliated Hospital of Guangxi Medical University