Association Between Three eNOS Polymorphisms and Cancer Risk: a Meta-analysis

Wu, Xun; Wang, Zhi-Feng; Xu, Yin; Ren, Rui; Heng, Bao-Li; Su, Ze-Xuan

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자료유형: 학술저널

저자정보: Wu, Xun (Department of Anatomy, School of Basic Medicine Science, Southern Medical University) Wang, Zhi-Feng (Department of Anatomy, School of Basic Medicine Science, Southern Medical University) Xu, Yin (Department of Urology, The First Affiliated Hospital of JINAN University) Ren, Rui (Department of Andrology, Zhongshan City People's Hospital) Heng, Bao-Li (Department of Urology, The First Affiliated Hospital of JINAN University) Su, Ze-Xuan (Department of Anatomy, School of Basic Medicine Science, Southern Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제13호

발행연도: 2014.1

수록면: 5,317 - 5,324 (8page)

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Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of cancer, but the results are still debatable. Therefore, we performed a systematic review to provide a more complete picture and conducted a meta-analysis to derive a precise estimation. We searched PubMed, EMBASE, EBSCO, Google Scholar and China National Knowledge Infrastructure (CNKI) databases until April 2014 to identify eligible studies. Thirty-one studies with cancer patients and controls were included in the meta-analysis. Overall, the polled analysis revealed that the T-786C polymorphism was significantly associated with increased cancer risk under multiple genetic models (C vs T: OR=1.135, 95%CI=1.048-1.228; CC vs TT: OR=1.278, 95%CI=1.045-1.562; TC vsTT: OR=1.136, 95%CI=1.023-1.261; CC+TC vs TT: OR=1.159, 95%CI=1.047-1.281; CC vs TC+TT: OR=1.204, 95%CI= 1.003-1.447). G894T was associated with significant risk for females (TT vs GG: OR=1.414, 95%CI=1.056-1.892; TT vs GT+GG: OR=1.356, 95%CI=1.108-1.661) and for breast cancer (T vs G: OR=1.097, 95%CI=1.001-1.203; TT vs GG: OR=1.346, 95%CI=1.012-1.789; TT vs GT+GG: OR=1.269, 95%CI=1.028-1.566). Increased susceptibility was revealed for prostate cancer with 4a/b (ba vs bb: OR=1.338, 95%CI=1.013-1.768; aa+ba vs bb: OR=1.474, 95%CI=1.002-2.170). This meta-analysis indicated that the eNOS T-786C polymorphism is associated with elevated cancer risk; the G894T polymorphism contributes to susceptibility to breast cancer and cancer generally in females; and the 4a/b polymorphism may be associated with prostate cancer risk.

#Endothelial nitric oxide synthase #polymorphism #cancer #systematic review #meta-analysis

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