PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

Fan, Fang-Tian; Shen, Cun-Si; Tao, Li; Tian, Chao; Liu, Zhao-Guo; Zhu, Zhi-Jie; Liu, Yu-Ping; Pei, Chang-Song; Wu, Hong-Yan; Zhang, Lei; Wang, Ai-Yun; Zheng, Shi-Zhong; Huang, Shi-Le; Lu, Yin

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자료유형: 학술저널

저자정보: Fan, Fang-Tian (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Shen, Cun-Si (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Tao, Li (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Tian, Chao (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Liu, Zhao-Guo (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Zhu, Zhi-Jie (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Liu, Yu-Ping (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Pei, Chang-Song (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Wu, Hong-Yan (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Zhang, Lei (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Wang, Ai-Yun (Department of Pharmacology, College of Pharmacy, Nanjing University of Chinese Medicine) Zheng, Shi-Zhong (Department) Huang, Shi-Le Lu, Yin

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제5호

발행연도: 2014.1

수록면: 1,961 - 1,970 (10page)

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Pyruvate kinase isozyme type M2 (PKM2) was first found in hepatocellular carcinoma (HCC), and its expression has been thought to correlate with prognosis. A large number of studies have demonstrated that epithelial-mesenchymal transition (EMT) is a crucial event in hepatocellular carcinoma (HCC) and associated metastasis, resulting in enhanced malignancy of HCC. However, the roles of PKM2 in HCC EMT and metastasis remain largely unknown. The present study aimed to determine the effects of PKM2 in EGF-induced HCC EMT and elucidate the molecular mechanisms in vitro. Our results showed that EGF promoted EMT in HCC cell lines as evidenced by altered morphology, expression of EMT-associated markers, and enhanced invasion capacity. Furthermore, the present study also revealed that nuclear translocation of PKM2, which is regulated by the ERK pathway, regulated ${\beta}$-catenin-TCF/LEF-1 transcriptional activity and associated EMT in HCC cell lines. These discoveries provide evidence of novel roles of PKM2 in the progression of HCC and potential therapeutic target for advanced cases.

#Epithelial growth factor receptor #PKM2 #${beta}$-catenin #epithelial-mesenchymal transition #HCC

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