The Prostaglandin Synthase 2/cyclooxygenase 2 (PTGS2/COX2) rs5277 Polymorphism Does not Influence Risk of Colorectal Cancer in an Iranian Population

Khorshidi, Fatemeh; Haghighi, Mahdi Montazer; Mojarad, Ehsan Nazemalhosseini; Azimzadeh, Pedram; Damavand, Behzad; Vahedi, Mohsen; Almasi, Shohreh; Aghdaei, Hamid Asadzadeh; Zali, Mohammad Reza

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저자정보: Khorshidi, Fatemeh (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Haghighi, Mahdi Montazer (Biology Department, Science faculty, Islamic Azad University) Mojarad, Ehsan Nazemalhosseini (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Azimzadeh, Pedram (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Damavand, Behzad (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Vahedi, Mohsen (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Almasi, Shohreh (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Aghdaei, Hamid Asadzadeh (Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Sciences) Zali, Mohammad Reza (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호

발행연도: 2014.1

수록면: 3,507 - 3,511 (5page)

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Background: The prostaglandin-endoperoxide synthase 2 [PTGS2, commonly known as cyclooxygenase-2 (COX-2)] is an enzyme induced by proinflammatory stimuli that is often overexpressed in malignant tissue and involved in the synthesis of prostaglandins and thromboxanes, regulators of processes such as inflammation, cell proliferation, and angiogenesis, all relevant for cancer development. We investigated whether a functional genetic polymorphism, rs5277, in COX-2 may have a risk-modifying effect on sporadic colorectal cancer in an Iranian population. Materials and Methods: We conducted a case-control study on 167 patients with colorectal cancer and 197 cancer-free controls in Taleghani Hospital in Tehran, Iran, between 2007 and 2011. Peripheral blood samples of both groups were processed for DNA extraction and genotyping of the COX-2 gene polymorphism (rs5277) using PCR-RFLP. RFLP results were confirmed by direct sequencing. Logistic regression analysis was performed to calculate the adjusted odds ratio (OR) and 95% confidence interval (95% CI). Results: There was no significant difference in the distribution of COX-2 gene rs5277 polymorphism genotype and the allelic form, among CRC patients compared with the healthy control group (p: 0.867). Conclusions: Our results suggest that rs5277 polymorphism in COX2 could not be a good prognostic indicator for patients with CRC.

#Colorectal cancer #cyclooxygenase-2 #genetic polymorphism #Iran

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Khorshidi, Fatemeh

소속기관 Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences