Evaluation of the Atlas Helicobacter pylori Stool Antigen Test for Diagnosis of Infection in Adult Patients

Osman, Hussein Ali; Hasan, Habsah; Suppian, Rapeah; Bahar, Norhaniza; Che Hussin, Nurzam Suhaila; Rahim, Amry Abdul; Hassan, Syed; Andee, Dzulkarnaen Zakaria; Zilfalil, Bin-Alwi

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저자정보: Osman, Hussein Ali (Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia) Hasan, Habsah (Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia) Suppian, Rapeah (Department of Biomedical Science, School of Health Sciences, Universiti Sains Malaysia) Bahar, Norhaniza (Department of Medicine, Hospital Kuala Lumpur) Che Hussin, Nurzam Suhaila (Department of Pathology, Hospital Kuala Lumpur) Rahim, Amry Abdul (Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia) Hassan, Syed (Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia) Andee, Dzulkarnaen Zakaria (Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia) Zilfalil, Bin-Alwi (Department of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제13호

발행연도: 2014.1

수록면: 5,245 - 5,247 (3page)

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Background: Helicobacter pylori (H.pylori) is one of the most important causes of dyspepsia and gastric cancer and diagnosis can be made by invasive or non-invasive methods. The Atlas Helicobacter pylori antigen test is a new rapid non-invasive method which is simple to conduct. The aim of this study was to determine its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy. Materials and Methods: This prospective study was conducted between July 2012 and December 2013. Stool samples of 59 dyspeptic patients who underwent upper endoscopy were evaluated for H. pylori stool antigen. Results: From the 59 patients who participated in this study, there were 36 (61%) males and 23 (39%) females. H. pylori was diagnosed in 24 (40.7%) gastric biopsies, 22 (91.7 %) of these being positive for the Atlas H. pylori antigen test. The sensitivity, specificity, PPV, NPV and accuracy were 91.7%, 100%, 100%, 94.6% and 96.6% respectively. Conclusions: The Atlas H. pylori antigen test is a new non-invasive method which is simple to perform and avails reliable results in a few minutes. Thus it can be the best option for the diagnosis of H. pylori infection due to its high sensitivity and specificity.

#Helicobacter pylori #sensitivity #specificity #Atlas H #pylori antigen test

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Osman, Hussein Ali

소속기관 Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Ma