Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Soliman, Nema Ali; Keshk, Walaa Arafa; Shoheib, Zeinab Salah; Ashour, Dalia Salah; Shamloula, Maha Moustafa

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자료유형: 학술저널

저자정보: Soliman, Nema Ali (Department of Medical Biochemistry, Faculty of Medicine, Tanta University) Keshk, Walaa Arafa (Department of Medical Biochemistry, Faculty of Medicine, Tanta University) Shoheib, Zeinab Salah (Department of Paracytology, Faculty of Medicine, Tanta University) Ashour, Dalia Salah (Department of Paracytology, Faculty of Medicine, Tanta University) Shamloula, Maha Moustafa (Department of Pathology, Faculty of Medicine, Tanta University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제3호

발행연도: 2014.1

수록면: 1,125 - 1,131 (7page)

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Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted upon 80 mice that were divided the control group (10 non infected mice) and infected group which was subdivided into 7 sub-groups (10 mice each) according to the time of sacrifaction in the post infection (p.i.) period, 10 mice being sacrificed every two weeks from 6 weeks p.i. to 18 weeks p.i. Tumor necrosis factor alpha (TNF-${\alpha}$), inducible nitric oxide synthase (iNOS), and pentraxin 3 (PTX3) levels were estimated by immunoassay. The L-fucose level, and thioredoxin reductase (TrxR) and lactate dehydrogenase (LDH) activities were also evaluated in colonic tissue. Results: The current study revealed statistically significant elevation in the studied biochemical markers especially at 16 and 18 weeks p.i. The results were confirmed by histopathological examination that revealed atypical architectural and cytological changes in the form of epithelial surface serration and nuclear hyper-chromatizia at 14, 16 and 18 weeks p.i. Conclusions: inflammation, oxidative stress and L-fucose together may form an important link between Schistosomal mansoni infection and colonic dysplasia and they can be new tools for prediction of colonic dysplasia development in experimental schistosomiasis.

#Schistosoma mansoni #colonic dysplasia #$TNF{alpha}$ #iNOS #PTX3 #L-fucose #TrxR #LDH

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