BMI1 and TWIST1 Downregulated mRNA Expression in Basal Cell Carcinoma

Rajabpour, Fatemeh Vand; Raoofian, Reza; Youssefian, Leila; Vahidnezhad, Hassan; Shahshahani, Mostafa Mirshams; Fathi, Hamidreza; Noormohammadpour, Pedram; Hesari, Kambiz Kamyab; Hashemzadeh-Chaleshtori, Morteza; Tabrizi, Mina

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자료유형: 학술저널

저자정보: Rajabpour, Fatemeh Vand (Cellular and Molecular Research Center, Shahrekord University of Medical Sciences) Raoofian, Reza (Medical Genetics Department, Tehran University of Medical Sciences) Youssefian, Leila (Medical Genetics Department, Tehran University of Medical Sciences) Vahidnezhad, Hassan (Medical Genetics Department, Tehran University of Medical Sciences) Shahshahani, Mostafa Mirshams (Tumor Clinic, Pathology Department and the Department of Plastic and Reconstructive Surgery, Razi Dermatology Hospital, Tehran University of Medical Sciences) Fathi, Hamidreza (Tumor Clinic, Pathology Department and the Department of Plastic and Reconstructive Surgery, Razi Dermatology Hospital, Tehran University of Medical Sciences) Noormohammadpour, Pedram (Tumor Clinic, Pathology Department and the Department of Plastic and Reconstructive Surgery, Razi Dermatology Hospital, Tehran University of Medical Sciences) Hesari, Kambiz Kamyab (Tumor Clinic, Pathology Department and the Department of Plastic and Reconstructive Surgery, Razi Dermatology Hospital, Tehran University of Medical Sciences) Hashemzadeh-Chaleshtori, Morteza (Cellular and Molecular Research Center, Shahrekord University of Medi) Tabrizi, Mina

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호

발행연도: 2014.1

수록면: 3,797 - 3,800 (4page)

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Background: BMI1, TWIST1 and SNAI2/SLUG have been implicated in aggressive behavior of squamous cell carcinoma (SCC) and melanoma and BMI1 expression could identify subtypes of Merkel cell carcinoma (MCC). However, BMI1, TWIST1 and SNAI2 expression levels in basal cell carcinomas (BCCs) have not been elucidated. We hypothesized BCC could be a good model system to decipher mechanisms which inhibit processes that drive tumor metastasis. The aim of this study was to examine the mRNA expression level of BMI1, TWIST1, and SNAI2 in BCCs. Materials and Methods: Thirty-five fresh non-metastatic BCC tissue samples and seven fresh normal skin tissue samples were evaluated by real-time RT-PCR. Results: BMI1 and TWIST1 demonstrated marked down-regulation (p<0.00l, p=0.00l respectively), but SNAI2 showed no significant change (p=0.12). Conclusions: Previous literature has clearly demonstrated a positive association between BMI1 and TWIST1 expression and metastatic BCC, aggressive SCC and melanoma. Here, we demonstrated a negative association between BMI1 and TWIST1 mRNA expression level and BCC.

#BMI1 #TWIST1 #SNAI2/SLUG #basal cell carcinoma #epithelial mesenchymal transition #metastasis

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