Establishment of and Comparison between Orthotopic Xenograft and Subcutaneous Xenograft Models of Gallbladder Carcinoma

Du, Qiang; Jiang, Lei; Wang, Xiao-Qian; Pan, Wei; She, Fei-Fei; Chen, Yan-Ling

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저자정보: Du, Qiang (Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University) Jiang, Lei (Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University) Wang, Xiao-Qian (Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University) Pan, Wei (Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University) She, Fei-Fei (Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University) Chen, Yan-Ling (Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호

발행연도: 2014.1

수록면: 3,747 - 3,752 (6page)

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Background: Gallbladder carcinoma (GBC) is the most common carcinoma of the biliary system. Among its research models, orthotopic xenograft models, important research tools, have been rarely reported in the literature however. Aim: To explore establishment of an orthotopic xenograft model and to evaluate the advantage and disadvantage as compared with other models. Materials and Methods: Subcutaneous xenograft and orthotopic xenograft models of gallbladder carcinoma in nude mice were established and compared with human gallbladder carcinomas. Results: For the orthotopic xenograft model and clinical gallbladder carcinomas, the lymph node metastatic rates were 69.2% and 53.3% (p>0.05); ascites generation rates, 38.5% and 11.7%(p<0.05); liver invasive rates, 100% and 61.7%(p<0.05); and lymphatic vessel densities (LVD), $10.4{\pm}3.02$ and $8.77{\pm}2.92$ (p>0.05), respectively. In the subcutaneous xenograft model, no evidence of ascites generation, lymph node metastasis and liver metastasis were found, and its LVD was lower ($4.56{\pm}1.53$, p<0.05). Conclusions: Compared with the subcutaneous xenograft model, the orthotopic xenograft model better simulates clinical gallbladder carcinoma in terms of metastasis and invasion, which may be attributed to the difference in microenvironment and LVD.

#Gallbladder carcinoma #orthotopic xenograft #subcutaneous xenograft #lympatic vessel density

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Du, Qiang

소속기관 Department of Hepatobiliary Surgery, The Affiliated Union Hospital of Fujian Medical University