Association of 8q24.21 rs10505477-rs6983267 Haplotype and Age at Diagnosis of Colorectal Cancer

Haerian, Monir Sadat; Haerian, Batoul Sadat; Rooki, Hassan; Molanaei, Saadat; Kosari, Farid; Obohhat, Maedeh; Hosseinpour, Parisa; Azimzadeh, Pedram; Mohebbi, Seyed Reza; Akbari, Zahra; Zali, Mohammad Reza

추천

검색

자료유형: 학술저널

저자정보: Haerian, Monir Sadat (Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical Science) Haerian, Batoul Sadat (Department of Pharmacology, Faculty of Medicine, University of Malaya) Rooki, Hassan (Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical Science) Molanaei, Saadat (Department of Pathology, Milad Hospital) Kosari, Farid (Department of Pathology, Sina Hospital, Tehran University of Medical Sciences) Obohhat, Maedeh (Department of Pathology, Sina Hospital, Tehran University of Medical Sciences) Hosseinpour, Parisa (Department of Pathology, Milad Hospital) Azimzadeh, Pedram (Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical Science) Mohebbi, Seyed Reza (Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical Science) Akbari, Zahra (Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical Science) Zali, Mohammad Reza (Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical Science)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제1호

발행연도: 2014.1

수록면: 369 - 374 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Colorectal cancer (CRC) is the fourth most common cause of cancer death in the world. Genetic variants in 8q24.21 including rs10505477 and rs6983267 have been hypothesized to be involved in susceptibility to CRC. This study aims to investigate the possible association between these loci and their haplotypes with CRC risk in Iranian population. Materials and Methods: Subjects were recruited from two hospitals in Tehran. The rs10505477 and rs6983267 polymorphisms were genotyped by TaqMan real time PCR using subject genomic DNA, extracted either from formalin-fixed, paraffin-embedded tissue of patients or from blood of the controls by standard methods. Results: A total of 715 subjects (380 CRC patients and 335 matched controls) were genotyped in this study. Allele and genotype analysis of the rs10505477 and rs6983267 polymorphisms by gender, age at diagnosis, tumor location, tumor grade, and tumor node metastasis (TNM) showed no significant association with CRC risk. There was a significant relationship between GG haplotype and susceptibility to age at diagnosis for both <60 and ${\geq}60$ (p=0.0005 and p=0.000004, respectively) and between GT and CRC in the age at diagnosis ${\geq}60$ (Table 3: p=0.031). The GG haplotype was less frequent in CRC patients with the age at diagnosis <60, but was more common in subjects with the age at diagnosis ${\geq}60$. Conclusions: Results of this study suggests that the rs6983267 and rs10505477 polymorphisms alone may not be relevant to CRC risk, but their GG haplotype plays a notable role in age at diagnosis of CRC in the Iranian population.

#Colorectal cancer #8q24 #21 #polymorphism #age at diagnosis #Iran

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Haerian, Monir Sadat

소속기관 Gastroenterology and Liver Diseases Research Center [GLDRC], Shahid Beheshti University of Medical S