Overexpression of Phospholipase A Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

Zhai, Yan-Chun; Dong, Bin; Wei, Wen-Qiang; He, Yan; Li, Xin-Qing; Cormier, Robert T.; Wang, Wei; Liu, Fen

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저자정보: Zhai, Yan-Chun (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Dong, Bin (Key Laboratory of Carcinogenesis and Translational Research [Ministry of Education], Central Laboratory, Peking University Cancer Hospital & Institute) Wei, Wen-Qiang (Department of Cancer Epidemiology, Cancer Institute, Peking Union Medical College, Chinese Academy of Medical Science) He, Yan (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Li, Xin-Qing (Department of Cancer Epidemiology, Cancer Institute, Peking Union Medical College, Chinese Academy of Medical Science) Cormier, Robert T. (Department of Biomedical Sciences, University of Minnesota Medical School Duluth) Wang, Wei (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University) Liu, Fen (Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제21호

발행연도: 2014.1

수록면: 9,417 - 9,421 (5page)

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Background: Esophageal cancer is one of the most frequently occurring malignancies and the seventh leading cause of cancer-related deaths in the world. The esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer worldwide. Materials and Methods: Our goal in this study was to detect phospholipase A2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) immuno-expression in ESCC in a high-risk population in China. Results: Positive expression of PLA2G2A protein was observed in 57.2% (166/290) of the cases, while COX-2 was found in 257 of 290 samples (88.6%), both PLA2G2A and COX-2 being expressed in 153 cases (52.8%), with a significant agreement (Kappa=0.091, p=0.031).Overexpression of PLA2G2A was significantly correlated with the depth of invasion (p=0.001). Co-expression of PLA2G2A and COX-2 not only significantly correlated with the depth of invasion (p=0.004) but also with TNM stage (p=0.04). Conclusions: Our results showed that in patients with ESCC, PLA2G2A overexpression and PLA2G2A co-expression with COX-2 is significantly correlated with advanced stage. The biological role and pathophysiologic regulation of PLA2G2A and COX-2 overexpression in ESCC deserve further investigation.

#Esophageal SCC #phospholipase $A_2$ group IIA #cyclooxygenase-2 #immunohistochemistry

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Zhai, Yan-Chun

소속기관 Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical Universit