Long-Term Treatment Results in Soft Tissue Sarcomas of the Thoracic Wall Treated with Pre-or-Postoperative Radiotherapy - a Single Institution Experience

Oksuz, Didem Colpan; Ozdemir, Sevim; Kaydihan, Nuri; Dervisoglu, Sergulen; Hiz, Murat; Tuzun, Hasan; Mandel, Nil Molinas; Koca, Sedat; Dincbas, Fazilet Oner

추천

검색

자료유형: 학술저널

저자정보: Oksuz, Didem Colpan (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) Ozdemir, Sevim (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) Kaydihan, Nuri (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) Dervisoglu, Sergulen (Department of Pathology, Istanbul University Cerrahpasa Medical Faculty) Hiz, Murat (Department of Orthopedic Surgery, Istanbul University Cerrahpasa Medical Faculty) Tuzun, Hasan (Department of Cardiovascular Surgery, Istanbul University Cerrahpasa Medical Faculty) Mandel, Nil Molinas (Department of Medical Oncology, Istanbul University, Cerrahpasa Medical Faculty) Koca, Sedat (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty) Dincbas, Fazilet Oner (Department of Radiation Oncology, Istanbul University Cerrahpasa Medical Faculty)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제22호

발행연도: 2014.1

수록면: 9,949 - 9,953 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objective: To evaluate the long term results among patients with soft tissue sarcoma of the thoracic wall. Materials and Methods: Twenty-six patients who were treated with pre-or postoperative radiotherapy between December 1980-December 2007, with a diagnosis of soft tissue sarcoma of the thoracic wall were retrospectively evaluated. Results: The median age was 44 years (14-85 years) and 15 of them were male. A total of 50% of patients were grade 3. The most common histologic type of tumor was undifferentiated pleomorphic sarcoma (26.9%). Tumor size varied between 2-25 cm (median 6.5 cm). Seventeen of the cases had marginal and 9 had wide local resection. Four cases received preoperative radiotherapy and 22 postoperative radiotherapy. Six of the patients with large and high grade tumors received chemotherapy. Median follow-up time was 82 months (9-309 months). Local recurrence and metastasis was detected in 34.6% and 42.3% of patients, respectively. Five-year local control (LC), disease-free survival (DFS), overall survival (OS), and disease-specific survival (DSS) were 62%, 38%, 69%, and 76% respectively. On univariate analysis, the patients with positive surgical margins had a markedly lower 5-year LC rate than patients with negative surgical margin, but the difference was not significant (43% vs 78%, p=0.1). Five-year DFS (66% vs 17%) and DSS (92% vs 60%) rates were significantly worse for the patients who had high grade tumors (p=0.01, p=0.008 respectively). Conclusions: Tumor grade and surgical margin are essential parameters for determining the prognosis of thoracic wall soft tissue sarcoma both in our series and the literature.

#Thoracic wall soft tissue sarcoma #prognostic factors #radiotherapy

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요