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자료유형
학술저널
저자정보
Xie, Ying (Guangxi Key Laboratory for High-incidence Tumor Prevention and Treatment, Experimental Center of Medical Science of Guangxi Medical University) Wei, Zheng-Bo (Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University) Duan, Xu-Wei (Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호
발행연도
2014.1
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3,547 - 3,553 (7page)

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Background: The prognostic value of serum alkaline phosphatase (S-ALP) has not been fully validated for nasopharyngeal carcinoma (NPC). Materials and Methods: S-ALP levels were measured in 601 patients newly diagnosed with NPC before radical treatment, and possible associations of these levels with 5-year overall survival (OS) and tumor-free survival (TFS) were explored using univariate and multivariate analyses. Results: Elevated pretreatment S-ALP (>85 U/L) was significantly less frequent among patients classified as T1+2 or stage I+II than among those classified as T3+4 or stage III+IV. Multivariate analysis showed that elevated pretreatment S-ALP (>85 U/L), age, T classification and N stage were independent predictors of poor OS and TFS. Conclusions: Pretreatment S-ALP may be a reliable biomarker to evaluate the long-term prognosis of patients with NPC.

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