Lack of Associations between Vitamin D Metabolism-Related Gene Variants and Risk of Colorectal Cancer

Mahmoudi, Touraj; Karimi, Khatoon; Arkani, Maral; Farahani, Hamid; Nobakht, Hossein; Dabiri, Reza; Asadi, Asadollah; Vahedi, Mohsen; Zali, Mohammad Reza

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자료유형: 학술저널

저자정보: Mahmoudi, Touraj (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Karimi, Khatoon (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Arkani, Maral (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences) Farahani, Hamid (Department of Physiology, School of Medicine, Qom University of Medical Sciences) Nobakht, Hossein (Internal Medicine Department, Semnan University of Medical Sciences) Dabiri, Reza (Internal Medicine Department, Semnan University of Medical Sciences) Asadi, Asadollah (Department of Biology, Faculty of Science, University of Mohaghegh Ardabili) Vahedi, Mohsen (Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences) Zali, Mohammad Reza (Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제2호

발행연도: 2014.1

수록면: 957 - 961 (5page)

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Purpose: With regard to the protective effect of vitamin D against colorectal cancer (CRC), we evaluated genetic variants that might influence vitamin D metabolism: vitamin D receptor (VDR), vitamin D binding protein (GC), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 25-hydroxy 1-alpha hydroxylase (CYP27B1). Materials and Methods: A total of 657 subjects, including 303 cases with CRC and 354 controls were enrolled in this case-control study. All 657 were genotyped for the four gene variants using PCR-RFLP methods. Results: In this study, no significant difference was observed for VDR (rs2238136), GC (rs4588), CYP2R1 (rs12794714), and CYP27B1 (rs3782130) gene variants in either genotype or allele frequencies between the cases with CRC and the controls and this lack of difference remained even after adjustment for age, BMI, sex, smoking status, NSAID use, and family history of CRC. Furthermore, no evidence for effect modification of the variants and CRC by BMI, sex, or tumor site was observed. Conclusions: Our findings do not support a role for VDR, GC, and CYP27B1 genes in CRC risk in our Iranian population. Another interesting finding, which to our knowledge has not been reported previously, was the lack of association with the CYP2R1 gene polymorphism. Nonetheless, our findings require confirmation and possible roles of vitamin D metabolism-related genes in carcinogenesis need to be further investigated.

#Colorectal cancer #CYP27B1 #CYP2R1 #GC #Variant #VDR #risk #lack of association

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Mahmoudi, Touraj

소속기관 Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences