Lack of any Prognostic Value of Body Mass Index for Patients Undergoing Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

Zhang, Fang; Wang, Chuan-Sheng; Sun, Bo; Tian, Guang-Bo; Cao, Fang-Li; Cheng, Yu-Feng

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자료유형: 학술저널

저자정보: Zhang, Fang (Cancer Centre, the First Hospital of Zibo) Wang, Chuan-Sheng (Cancer Centre, the First Hospital of Zibo) Sun, Bo (Cancer Centre, the First Hospital of Zibo) Tian, Guang-Bo (Cancer Centre, the First Hospital of Zibo) Cao, Fang-Li (Cancer Centre, Liaocheng People's Hospital) Cheng, Yu-Feng (Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제7호

발행연도: 2014.1

수록면: 3,075 - 3,079 (5page)

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Background: The relationship between body mass index(BMI) and outcomes after chemoradiotherapy(CRT) has not been systematically addressed. The purpose of this study was to evaluate the effect of BMI on survival in patients with esophageal squamous cell carcinoma (ESCC). Materials and Methods: Sixty ESCC cases were retrospectively reviewed in this study. Patient overall survival(OS) and disease-free survival (DFS) were compared between two groups (BMI< $24.00kg/m^2$ and $BMI{\geq}24.00kg/m^2$). Results: There were 41 patients in the low/normal BMI group (BMI< $24.00kg/m^2$) and 19 in the high BMI group ($BMI{\geq}24.00kg/m^2$). No significant differences were observed in patient characteristics between these. We found no difference in 2-year OS and DFS associated with BMI (p=0.763 for OS; p=0.818 for DFS) using the Kaplan-Meier method. Univariate analysis revealed that higher clinical stage was prognostic for worse 2-year OS and DFS, metastasis for 2-year OS, lymph node status for 2-year DFS, while age, gender, smoking, drinking, tumor location and BMI were not prognostic. There were no differences in the 2-year OS (hazard ratio=1.117; p=0.789) and DFS(hazard ratio=1.161; p=0.708) between BMI groups in multivariate analysis, whereas we found statistical differences in the 2-year OS and DFS associated with clinical stage, gender and tumor infiltration (p<0.04), independent of age, smoking, drinking, tumor location, the status of lymph node metastases and BMI. Conclusions: BMI was not associated with survival in patients with ESCC treated with CRT as primary therapy. BMI should not be considered a prognostic factor for patients undergoing CRT for ESCC.

#Squamous cell carcinoma #esophageal neoplasms #survival #body mass index #chemoradiotherapy

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