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논문 기본 정보

자료유형
학술저널
저자정보
Wang, Xue-Jian (School of Pharmacy and Biology Science, Weifang Medical University) Zhang, Xiu-Rong (School of Pharmacy and Biology Science, Weifang Medical University) Zhang, Lei (School of Medicine, Qingdao University) Li, Qing-Hua (School of Public Health, Weifang Medical University) Wang, Lin (School of Pharmacy and Biology Science, Weifang Medical University) Shi, Li-Hong (School of Pharmacy and Biology Science, Weifang Medical University) Fang, Chun-Yan (School of Pharmacy and Biology Science, Weifang Medical University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제8호
발행연도
2014.1
수록면
3,397 - 3,401 (5page)

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Determining cell quantity is a common problem in cytology research and anti-tumor drug development. A simple and low-cost method was developed to determine monolayer and adherent-growth cell quantities. The cell nucleus is located in the cytoplasm, and is independent. Thus, the nucleus cannot make contact even if the cell density is heavy. This phenomenon is the foundation of accurate cell-nucleus recognition. The cell nucleus is easily recognizable in images after fluorescent staining because it is independent. A one-to-one relationship exists between the nucleus and the cell; therefore, this method can be used to determine the quantity of proliferating cells. Results indicated that the activity of the histone deacetylase inhibitor Z1 was effective after this method was used. The nude-mouse xenograft model also revealed the potent anti-tumor activity of Z1. This research presents a new anti-tumor-drug evaluation method.

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