Outcome of Intestinal Metaplasia in Gastric Biopsy of Patients with Dyspepsia in Guilan Province, North Iran

Mansour-Ghanaei, Fariborz; Joukar, Farahnaz; Soati, Fatemeh; Mansour-Ghanaei, Alireza; Atrkar-Roushan, Zahra

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자료유형: 학술저널

저자정보: Mansour-Ghanaei, Fariborz (Division of Gastroenterology and Hepatology, Guilan University of Medical Sciences) Joukar, Farahnaz (Gastrointestinal and Liver Diseases Research Center [GLDRC], Guilan University of Medical Sciences) Soati, Fatemeh (Gastrointestinal and Liver Diseases Research Center [GLDRC], Guilan University of Medical Sciences) Mansour-Ghanaei, Alireza (Shahid Beheshti University of Medical Sciences) Atrkar-Roushan, Zahra (Gastrointestinal and Liver Diseases Research Center [GLDRC], Guilan University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,549 - 3,554 (6page)

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Background: It is generally accepted that gastric carcinomas are preceded by a sequential multistage process that includes chronic gastritis, gastric atrophy, usually with intestinal metaplasia (IM), and dysplasia. This series of changes in gastric carcinogenesis is often initiated by Helicobacter pylori (H pylori) infection. The aim of the present study was determination of gastric histopathologic changes in IM patients after at least one year in Guilan province, Iran. Materials and Methods: This case-series study was conducted in Guilan Gastrointestinal and Liver Disease Research Center (GLDRC) during 2010 to 2011. Gastric biopsy was performed for all 71 known cases of IM and precanceric lesions including gastric atrophy, IM, dysplasia and H pylori infection were determined after at least one year. Results: Of the total of 71 patients with established IM who were enrolled, 50 had complete-type IM and 21 had incomplete-type IM. Fifty two people had H pylori infection. H pylori eradication was achieved in 39 patients (75%). Secondary pathology findings of patients with IM were complete metaplasia (39.4%), incomplete metaplasia (32.4%), dysplasia (23.9%) and other precanceric lesions (4.2%). Dysplasia (20%vs 33%) occurred in patients who had complete and incomplete IM at baseline respectively (p>0.05). Age, gender, family history of gastric cancer(GC); smoking habits and NSAIDs use were not associated with gastric premalignant lesions in initial and secondary pathologies (p>0.05). The difference became statistically significant between H pylori infection in patients with more than 3 years diagnostic intervals (p<0.05). Statistical difference between eradicators and non-eradicators was not significant. Conclusions: We found that incomplete IM increased the risk of subsequent dysplasia in this study.

#H pylori infection #histopathologic changes #intestinal metaplasia

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Mansour-Ghanaei, Fariborz

소속기관 Department of Gastroenterology, Gastrointestinal and Liver Diseases Research Center [GLDRC], Guilan