Regulatory Mechanisms of Annexin-Induced Chemotherapy Resistance in Cisplatin Resistant Lung Adenocarcinoma

Wang, Chao; Xiao, Qian; Li, Yu-Wen; Zhao, Chao; Jia, Na; Li, Rui-Li; Cao, Shan-Shan; Cui, Jia; Wang, Lu; Wu, Yin; Wen, Ai-Dong

추천

검색

자료유형: 학술저널

저자정보: Wang, Chao (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Xiao, Qian (Department of Dermatology, Xijing Hospital, Fourth Military Medical University) Li, Yu-Wen (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Zhao, Chao (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Jia, Na (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Li, Rui-Li (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Cao, Shan-Shan (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Cui, Jia (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Wang, Lu (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Wu, Yin (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University) Wen, Ai-Dong (Department of Pharmacy, Xijing Hospital, Fourth Military Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제7호

발행연도: 2014.1

수록면: 3,191 - 3,194 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Adenocarcinoma of lung has high incidence and a poor prognosis, woith chemotherapy as the main therapeutic tool, most commonly with cisplatin. However, chemotherapy resistance develops in the majority of patients during clinic treatment. Mechanisms of resistance are complex and still unclear. Although annexin play important roles in various tumor resistance mechanisms, their actions in cisplatin-resistant lung adenocarcinoma remain unclear. Preliminary studies by our group found that in cisplatin-resistant lung cancer A549 cells and lung adenocarcinoma tissues, both mRNA and protein expression of annexins A1, A2 and A3 is increased. Using a library of annexin A1, A2 and A3 targeting combined molecules already established by ourselves we found that specific targeting decreased cisplatin-resistance. Taken together, the underlined effects of annexins A1, A2 and A3 on drug resistance and suggest molecular mechanisms in cisplatin-resistant A549 cells both in vivo and in vitro. Furthermore, the study points to improved research on occurrence and development of lung adenocarcinoma, with provision of effective targets and programmes for lung adenocarcinoma therapy in the clinic.

#Annexin #lung adenocarcinoma #chemotherapy #effective targets

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요