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논문 기본 정보

자료유형
학술저널
저자정보
Kafshdooz, Taiebeh (Tabriz University of Medical Sciences, International Branche Aras) Tabrizi, Ali Dastranj (Womens Reroductive Health Research Center) Ardabili, Seyyed Mojtaba Mohaddes (Tabriz University of Medical Sciences Medical Faculty) Kafshdooz, Leila (Tabriz University of Medical Sciences, International Branche Aras) Ghojazadeh, Morteza (Womens Reroductive Health Research Center) Gharesouran, Jalal (Tabriz University of Medical Sciences Medical Faculty) Abdii, Ali (Womens Reroductive Health Research Center) Alizadeh, Hamideh (Tabriz University of Medical Sciences, International Branche Aras)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제22호
발행연도
2014.1
수록면
9,603 - 9,606 (4page)

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Background: Endometrial cancer is the fourth most common cancer among women in developed countries. Patients with endometrial cancer may benefit from systemic chemotherapy alone or in combination with targeted therapies if the disease is clinically diagnosed prior to spread and metastasis to other organs. The aim of this study was to evaluate the prognostic role of p53 polymorphism and its correlation with tumor grade in human uterine endometrial carcinomas. Materials and Methods: A total of 75 patients with endometrial carcinomas were studied for possible mutations in exon 4 of the p53 gene using polymerase chain reaction and restricting fragment length polymorphism techniques and sequencing. Results: In recent study, The rate of homozygote genotype of pro/pro or Arg/Arg in high grade group was higher than in comparison with low grade one. In addition samples that were undigested in RFLP, showed mutation in exone 4. Conclusions: Our findings showed that high grade endometrial carcinomas are highly associated with TP53 polymorphisms in comparison with low grades.

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