Increased Sister Chromatid Exchange in Peripheral Blood Lymphocytes from Humans Exposed to Pesticide: Evidence Based on a Meta-analysis

Yang, Hai-Yan; Liu, Jing; Yang, Si-Yu; Wang, Hai-Yu; Wang, Ya-Dong

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자료유형: 학술저널

저자정보: Yang, Hai-Yan (Department of Epidemiology, School of Public Health, Zhengzhou University) Liu, Jing (Department of Epidemiology, School of Public Health, Zhengzhou University) Yang, Si-Yu (Department of Epidemiology, School of Public Health, Zhengzhou University) Wang, Hai-Yu (Department of Toxicology, Henan Center for Disease Control and Prevention) Wang, Ya-Dong (Department of Toxicology, Henan Center for Disease Control and Prevention)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제15권 제22호

발행연도: 2014.1

수록면: 9,725 - 9,730 (6page)

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Background: Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure. Objective: To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide. Materials and Methods: Meta-analysis on the association between SCE frequency and pesticide exposure was performed with STATA 10.0 software package and Review Manager 5.0.24 in this study. Results: The overall means of SCE were 7.88 [95% confidence intervals (95%CI): 6.71-9.04] for exposure group and 6.05 (95%CI: 5.13-6.95) for controls, respectively. There was statistically significant difference in the SCE frequency in human peripheral blood lymphocytes between pesticide-exposed groups and control groups, and the summary estimate of weighted mean difference was 1.69 (95%CI: 1.01-2.38). We also observed that pesticide-exposed population had significantly higher SCE frequency than control groups among smokers, nonsmokers, pesticide applicator, pesticide producer, other exposure population and Asian population in stratified analyses. Conclusions: Data indicate that the SCE frequency in human peripheral blood lymphocytes might be an indicator of early genetic esffects for pesticide-exposed populations.

#Sister chromatid exchange #pesticide #peripheral blood lymphocytes #meta-analysis

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