A Multicenter Matched Case Control Study of Breast Cancer Risk Factors among Women in Karachi, Pakistan

Shamsi, Uzma; Khan, Shaista; Usman, Sheheryar; Soomro, Saleem; Azam, Iqbal

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저자정보: Shamsi, Uzma (Epidemiology and Biostatistics, Department of Community Health Sciences, Aga Khan University Hospital) Khan, Shaista (Department of Surgery, Aga Khan University Hospital) Usman, Sheheryar (Department of Medicine, P.A.F Hospital) Soomro, Saleem (Department of Surgery, Jinnah Postgraduate Medical Center) Azam, Iqbal (Epidemiology and Biostatistics, Department of Community Health Sciences, Aga Khan University Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 183 - 188 (6page)

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Background: Breast cancer (BC), the most common female cancer in Pakistan, is associated with a very high mortality. However, the roles of individual risk factors for BC among Pakistani women are still controversial. To assess potential risk factors for BC, a matched case-control study was conducted in two tertiary care hospitals of Karachi, Pakistan. Materials and Methods: The study population included 297 pathologically confirmed incident cases of BC patients diagnosed between January 2009 and December 2010. 586 controls without any history of BC were matched on hospital and ${\pm}5$ years of ages. Results: Positive family history of BC (MOR=1.72; 95%CI: 1.10, 2.80 for first degree vs. none), single marital status (MOR=1.55; 95%CI: 1.10, 2.39 for single/divorced/widowed women vs. married women), older age at menopause (MOR=3.92; 95%CI: 2.52, 6.18 for menopausal women aged below 45 years, MOR=6.42; 95%CI: 3.47, 11.98 for menopausal women above 45 years of age compared with premenopausal women) conferred an increased risk of BC for women. Increasing parity decreased the risk of BC (MOR=0.90; 95%CI: 0.85, 0.97 for each live birth). Intake of Vitamin D supplements (MOR=0.30; 95%CI: 0.12, 0.81 for ${\leq}3$ years and MOR=0.27; 95%CI: 0.13, 0.56 for >3 years) was protective compared to non-users of Vitamin D. Conclusions: This study confirmed only few of the recognized risk factors in Pakistani women. The protective effect of Vitamin D is important from public health perspective and needs to be further explored through a randomized controlled trial.

#Breast cancer #risk factors #vitamin D #matched case control study #Pakistani women

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Shamsi, Uzma

소속기관 Epidemiology and Biostatistics, Department of Community Health Sciences, Aga Khan University Hospita