Roles of Fibroblast Growth Factor-inducible 14 in Hepatocellular Carcinoma

Li, Nan; Hu, Wen-Jun; Shi, Jie; Xue, Jie; Guo, Wei-Xing; Zhang, Yang; Guan, Dong-Xian; Liu, Shu-Peng; Cheng, Yu-Qiang; Wu, Meng-Chao; Xie, Dong; Liu, Shan-Rong; Cheng, Shu-Qun

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자료유형: 학술저널

저자정보: Li, Nan (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Hu, Wen-Jun (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Shi, Jie (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Xue, Jie (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Guo, Wei-Xing (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Zhang, Yang (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Guan, Dong-Xian (Institute of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences) Liu, Shu-Peng (Changhai Hospital, The Second Military Medical University) Cheng, Yu-Qiang (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Wu, Meng-Chao (Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University) Xie, Dong (Institute of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences) Liu, Shan-Rong (Changhai Hospital, The Second Military Medical University) Cheng, Shu-Qun (East)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제6호

발행연도: 2013.1

수록면: 3,509 - 3,514 (6page)

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The prognostic value of the fibroblast growth factor-inducible 14 (Fn14) expression in hepatocellular carcinoma (HCC) is unknown. Real-time PCR (RT-PCR), western blot assays and immunohistochemistry analysis were here performed in order to compare Fn14 expressios in paired liver samples of HCC and normal liver tissue. Most of the tumor tissues expressed significantly higher levels of Fn14 compared to adjacent non-tumor tissues, with Fn14High accounting for 54.6% (142/260) of all patients. The Pearson ${\chi}^2$ test indicated that Fn14 expression was closely associated with serum alpha fetal protein (AFP) (P=0.002) and tumor number (p=0.019). Univariate and multivariate analyses revealed that along with tumor diameter and portal vein tumor thrombosis (PVTT ) type, Fn14 was an independent prognostic factor for both overall survival (OS) (HR=1.398, p=0.008) and recurrence (HR=1.541, p=0.001) rates. Fn14 overexpression HCC correlated with poor surgical outcome, and this molecule may be a candidate biomarker for prognosis as well as a target for therapy.

#Fibroblast growth factor-inducible 14 #hepatocellular carcinoma #portal vein tumor thrombosis #prognosis

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