Genetic Polymorphisms of Glutathione S-transferase M1 and Prostate Cancer Risk in Asians: A Meta-analysis of 18 Studies

Hu, Zheng-Hui; Lin, Yi-Wei; Xu, Xin; Chen, Hong; Mao, Ye-Qing; Wu, Jian; Zhu, Yi; Xu, Xiang-Lai; Xie, Li-Ping

추천

검색

자료유형: 학술저널

저자정보: Hu, Zheng-Hui (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Lin, Yi-Wei (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Xu, Xin (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Chen, Hong (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Mao, Ye-Qing (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Wu, Jian (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Zhu, Yi (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Xu, Xiang-Lai (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University) Xie, Li-Ping (Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 393 - 398 (6page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: Many studies have investigated associations between the glutathione S-transferase M1 (GSTM1) null polymorphism and risk of prostate cancer, but the impact of GSTM1 in people who live in Asian countries is still unclear owing to inconsistencies across results. Methods: We searched the PubMed, Web of Science, Scopus, Ovid and CNKI databases for studies of associations between the GSTM1 null genotype and risk of prostate cancer in people who live in Asian countries, and estimated summary odds ratios (ORs) with 95% confidence intervals (95% CIs). Results: A total of 18 case-control studies with 2,172 cases and 3,258 controls were included in this meta-analysis, which showed the GSTM1 null genotype to be significantly associated with increased risk of prostate cancer in people who live in Asian countries (random-effects OR=1.74, 95% CI1.44-2.09, P<0.001). Similar results were found in East Asians (OR=1.41; 95% CI: 1.12-1.78; P=0.004) and Caucasians in Asia (OR=2.19; 95% CI: 1.85-2.60; P<0.001). No evidence of publication bias was observed. Conclusions: This meta-analysis of available data suggested that the GSTM1 null genotype does contribute to increased risk of prostate cancer in people who live in Asian countries.

#Glutathione-S-transferase M1 #prostate cancer #gene polymorphism #meta-analysis

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Hu, Zheng-Hui

소속기관 Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University