Screening of MicroRNA in Patients with Esophageal Cancer at Same Tumor Node Metastasis Stage with Different Prognoses

Zhao, Bao-Sheng; Liu, Shang-Guo; Wang, Tian-Yun; Ji, Ying-Hua; Qi, Bo; Tao, Yi-Peng; Li, Han-Chen; Wu, Xiang-Nan

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자료유형: 학술저널

저자정보: Zhao, Bao-Sheng (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University) Liu, Shang-Guo (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University) Wang, Tian-Yun (Department of Biochemistry and Molecular Biology, Xinxiang Medical University) Ji, Ying-Hua (Department of Oncology, the First Affiliated Hospital of Xinxiang Medical University) Qi, Bo (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University) Tao, Yi-Peng (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University) Li, Han-Chen (Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University) Wu, Xiang-Nan (Department of Biochemistry and Molecular Biology, Xinxiang Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 139 - 143 (5page)

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Patients at the same pathological stage of esophageal cancer (EC) that received the same surgical therapy by the same surgeon may have distinct prognoses. The current study aimed to explore the possibility of differentially-expressed microRNAs (miRNAs) underlying this phenomenon. Samples were collected from EC patients at the same tumor node metastasis (TNM) stage but with different prognoses. Paracancerous normal tissues were taken as controls. The specimens were histopathologically analyzed. Differentially-expressed miRNAs were analyzed using real-time quantitative reverse transcription polymerase chain reaction. Compared with patients with poor prognosis, those with good prognosis exhibited 88 two-fold or more than two-fold increased miRNA fragments and 4 half-decreased miRNAs. The most noticeably up-regulated miRNAs included hsa-miR-31, hsa-miR-196b, hsa-miR-652, hsa-miR-125a-5p, hsa-miR-146b, hsa-miR-200c, hsa-miR-23b, hsa-miR-29a, hsa-miR-186, hsa-miR-205, hsa-miR-376a, hsa-miR-410, hsa-miR-532-3p, and hsa-miR-598, whereas the most significantly-downregulated miRNAs were hsa-let-7e, hsa-miR-130b, and hsa-miR-103. EC patients at same TNM stage but with different prognoses show differentially-expressed miRNAs.

#Esophageal cancer #tumor node metastasis #TNM) #prognosis #microRNA

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Zhao, Bao-Sheng

소속기관 Department of Thoracic Surgery, the First Affiliated Hospital of Xinxiang Medical University