Endostar Combined with Cisplatin Inhibits Tumor Growth and Lymphatic Metastasis of Lewis Lung Carcinoma Xenografts in Mice

Dong, Xiao-Peng; Xiao, Tian-Hui; Dong, Hong; Jiang, Ning; Zhao, Xiao-Gang

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자료유형: 학술저널

저자정보: Dong, Xiao-Peng (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) Xiao, Tian-Hui (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) Dong, Hong (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) Jiang, Ning (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University) Zhao, Xiao-Gang (Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제5호

발행연도: 2013.1

수록면: 3,079 - 3,083 (5page)

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Objective: To investigate the effects of endostar, a recombined humanized endostatin, plus cisplatin on the growth, lymphangiogenesis and lymphatic metastasis of the Lewis lung carcinoma (LLC) in mice. Methods: A tumor model were established in C57BL/6 mice by intravenious transplantation of LLC cells. Then the mice were randomized to receive administration with NS, endostar, cisplatin, or endostar plus cisplatin. After the mice were sacrificed, tumor multiplicity, tumor size and lymph node metastasis were assessed. Then the expression of vascular endothelial growth factor-c (VEGF-C) and podoplanin were determined by immunohistochemical staining. Results: Endostar plus cisplatin significantly suppressed tumor growth. lymphatic metastasis and prolonged survival time of the mice without obvious toxicity. The inhibition of lymphatic metastasis was associated with decreased microlymphatic vessel density (MLVD) and expression of VEGF-C. Conclusions: Endostar combined with cisplatin was more effective to suppress tumor growth and lymphatic metastasis than either agent alone. Thus this may provide a rational alternative for lung carcinoma treatment.

#Lung tumor #endostatin #cisplatin #lymphangiogenesis

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Dong, Xiao-Peng

소속기관 Department of Thoracic Surgery, Second Hospital of Shandong University, Shandong University