Diabetes Mellitus Reduces Prostate Cancer Risk - No Function of Age at Diagnosis or Duration of Disease

Xu, Hua; Mao, Shan-Hua; Ding, Guan-Xiong; Ding, Qiang; Jiang, Hao-Wen

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저자정보: Xu, Hua (Department of Urology, Huashan Hospital, Fudan University) Mao, Shan-Hua (Department of Urology, Huashan Hospital, Fudan University) Ding, Guan-Xiong (Department of Urology, Huashan Hospital, Fudan University) Ding, Qiang (Department of Urology, Huashan Hospital, Fudan University) Jiang, Hao-Wen (Department of Urology, Huashan Hospital, Fudan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 441 - 447 (7page)

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Background: Prior studies examining the relation between diabetes mellitus (DM) and prostate cancer risk have reported controversial findings. We examined this association by conducting a detailed meta-analysis of the peer-reviewed literature. Methods: A comprehensive search for articles of MEDLINE and EMBASE databases and bibliographies of retrieved articles published up to November, 2012 was performed. Methodological quality assessment of the trials was based on the Newcastle-Ottawa Scaleq and the meta-analysis was performed using STATA 12.0. Dose-response regression was conducted with SPSS 19.0. Results: We included 29 studies in the meta-analysis (13 case-control studies, 16 cohort studies), and found an inverse association between DM and prostate cancer (relative risk (RR) 0.84, 95% confidence interval (CI), 0.78-0.91). An inverse association was also observed in non-Asian populations (RR 0.81, 95% CI 0.76-0.87) and population-based studies (RR 0.80, 95% CI 0.77-0.91). No statistical significance was found of the association between prostate cancer risk and the duration of DM (p=0.338), and risk seemed not related with the age of DM diagnosis. Conclusions: This study suggested an inverse relationship between DM and prostate cancer, but without links to duration of disease or age of diagnosis.

#Diabetes mellitus #meta-analysis #prostate cancer

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Xu, Hua

소속기관 Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and T