Value of Postoperative Radiation Therapy for Regional Control after Dissection in Head and Neck Squamous Cell Carcinoma Cases

Li, Xiao-Ming; Di, Bin; Shang, Yao-Dong; Tao, Zhen-Feng; Cheng, Ji-Min; He, Zhan-Guo

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저자정보: Li, Xiao-Ming (Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital) Di, Bin (Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital) Shang, Yao-Dong (Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital) Tao, Zhen-Feng (Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital) Cheng, Ji-Min (Department of Pathology, Bethune International Peace Hospital) He, Zhan-Guo (Department of Pathology, Bethune International Peace Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제7호

발행연도: 2013.1

수록면: 4,273 - 4,278 (6page)

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Objective: We aimed to define clinicopathologic risk factors associated with regional recurrence (RR) and thus the effectiveness of postoperative radiotherapy (PORT) for neck control for head and neck squamous cell carcinomas (HNSCCs) with differing cervical lymph node status. Methods: A retrospective study was performed in 196 HNSCC patients with pathologically positive neck node (N+) to evaluate the high-risk factors for RR and to define the role of PORT in control after neck dissection and postoperative radiotherapy (PORT). Results: Overall, the RR rate after neck dissection and PORT was 29%. Extracapsular spread (ECS) was confirmed to be the only independent risk factor for RR. There were no significant risk factors associated with RR in the ECS- group. The 5-year disease-specific survival rate was 45%, which descended to 10% with the emergence of RR. Conclusions: ECS remains a determined risk factor for RR after neck dissection and PORT in patients with N+. PORT alone is not adequate for preventing RR in the neck with ECS after neck dissection. More intensive postoperative adjuvant therapies, especially combined chemotherapy and radiotherapy, are needed to prevent regional failure in HNSCC patients with ECS.

#HNSCC #neck node metastasis #dissection #postoperative radiotherapy #regional recurrence

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Li, Xiao-Ming

소속기관 Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital