Interleukin-10 Gene Promoter Polymorphisms and Risk of Gastric Cancer in a Chinese Population: Single Nucleotide and Haplotype Analyses

Pan, Xiong-Fei; Yang, Shu-Juan; Loh, Marie; Xie, Yao; Wen, Yuan-Yuan; Tian, Zhi; Huang, He; Lan, Hui; Chen, Feng; Soong, Richie; Yang, Chun-Xia

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저자정보: Pan, Xiong-Fei (Department of Epidemiology, West China School of Public Health, Sichuan University) Yang, Shu-Juan (Department of Child and Adolescent Health, West China School of Public Health, Sichuan University) Loh, Marie (Cancer Science Institute of Singapore, National University of Singapore) Xie, Yao (Department of Epidemiology, West China School of Public Health, Sichuan University) Wen, Yuan-Yuan (Department of Epidemiology, West China School of Public Health, Sichuan University) Tian, Zhi (Department of Epidemiology, West China School of Public Health, Sichuan University) Huang, He (Department of Epidemiology, West China School of Public Health, Sichuan University) Lan, Hui (Department of Epidemiology, West China School of Public Health, Sichuan University) Chen, Feng (Department of Epidemiology, West China School of Public Health, Sichuan University) Soong, Richie (Cancer Science Institute of Singapore, National University of Singapore) Yang, Chun-Xia (Department of Epidemiology, West China School of Public Health, Sichuan University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제4호

발행연도: 2013.1

수록면: 2,577 - 2,582 (6page)

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Objectives: Interleukin (IL) -10 is a potent cytokine with a dual ability to immunosuppress or immunostimulate. We aimed to explore the association of IL10 promoter polymorphisms with risk of gastric cancer (GC) in a Han population in Southwestern China. Methods: We enrolled 308 pairs of GC and control subjects from four hospitals and a community between October 2010 and August 2011 in a 1:1 matched case-control design. Demographic information was collected using a designed questionnaire. IL10-592 A>C and IL10-1082 A>G polymorphisms were determined by Sequenom MassARRAY analysis. Results: Patients with GC reported statistically higher proportions of family history of cancer (29.9% versus 10.7%, P<0.01) and alcohol drinking (54.6% versus 43.2%, P<0.01) than did controls. Similar results were observed in comparison between non-cardia GC patients and controls (P<0.01 and P=0.03). Variant genotypes of IL10-592 A>C and IL10-1082 A>G were not associated with overall GC risk (adjusted OR, 0.94, 95% CI, 0.66-1.33; adjusted OR, 1.00, 95% CI, 0.62-1.60). Sub-analysis showed that the IL10-592 AC/CC variant genotype was associated with decreased non-cardia GC risk (adjusted OR, 0.58; 95% CI, 0.36-0.95). No association was found between any of the IL10 haplotypes established from two polymorphisms and risk of non-cardia GC. Conclusions: In conclusion, our data do not link the two SNPs of IL10-592 and IL10-1082 with overall GC risk. We demonstrate that IL10-592 polymorphism is associated with protective effect against non-cardia GC. Our findings may offer insight into risk associated with the development of GC in this region.

#Gastric cancer #interleukin-10 gene #polymorphism #risk #case-control study

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