Immunoregulatory Function of HLA-G in Gastric Cancer

Tuncel, Tolga; Karagoz, Bulent; Haholu, Aptullah; Ozgun, Alpaslan; Emirzeoglu, Levent; Bilgi, Oguz; Kandemir, Emin Gokhan

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저자정보: Tuncel, Tolga (Department of Medical Oncology, Gata Haydarpasa Training Hospital) Karagoz, Bulent (Department of Medical Oncology, Gata Haydarpasa Training Hospital) Haholu, Aptullah (Department of Pathology, Gata Haydarpasa Training Hospital) Ozgun, Alpaslan (Department of Medical Oncology, Gata Haydarpasa Training Hospital) Emirzeoglu, Levent (Department of Medical Oncology, Gata Haydarpasa Training Hospital) Bilgi, Oguz (Department of Medical Oncology, Gata Haydarpasa Training Hospital) Kandemir, Emin Gokhan (Department of Medical Oncology, Gata Haydarpasa Training Hospital)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호

발행연도: 2013.1

수록면: 7,681 - 7,684 (4page)

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Background: Human leukocyte antigen (HLA)-G-positive gastric cancers are associated with poor survival, but links with tumor escape mechanisms remain to be determined. Materials and Methods: We used immunohistochemistry to investigate HLA-G expression, tumor infiltrating CD8+ T lymphocytes, and Treg cells in 52 gastric cancer patients. Results: There were 29 cancer-related deaths during the follow-up period. Kaplan-Meier analysis indicated that patients with HLA-G-positive (n=16) primary tumors had a significantly poorer prognosis than patients with HLA-G-negative tumors (n=36, p=0.008). The median survival time was 14 months and 47 months, respectively. Patients with high numbers of Tregs and low numbers of CD8+T lymphocytes in the primary tumor had a poorer prognosis than those with low numbers of Tregs and high numbers of CD8+T lymphocytes (p=0.034, p=0.043). Multivariate Cox proportional hazard regression analysis showed that HLA-G expression (hazard ratio: 2.662; 95% confidence interval: 1.242-5.723; p=0.012) and stage (hazard ratio: 2.012;95% confidence interval: 1.112-3.715; p=0.041) were independent unfavorable factors for patient survival. Conclusions: We found a significant positive correlation between HLA-G expression and the number of tumor infiltrating Tregs (p=0.01) and a negative correlation with the number of CD8+T lymphocytes (p=0.041). HLA-G may protect gastric cancer cells from cytolysis by inducing Foxp3+Treg lymphocytes and suppressing CD8+T lymphocytes.

#HLA-G #gastric cancer #CD8 T lymphocytes #treg cells

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Tuncel, Tolga

소속기관 Department of Medical Oncology, Gulhane Military Medical Academy, Haydarpasa Training Hospital