EA-D p45-IgG as a Potential Biomarker for Nasopharyngeal Carcinoma Diagnosis

Chen, Hao; Luo, Yao-Ling; Zhang, Lin; Tian, Li-Zhen; Feng, Zhi-Ting; Liu, Wan-Li

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자료유형: 학술저널

저자정보: Chen, Hao (Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine) Luo, Yao-Ling (Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine) Zhang, Lin (Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine) Tian, Li-Zhen (Department of Clinical Laboratory, Guangzhou Drug Administration Hospital) Feng, Zhi-Ting (First Affiliated Hospital of Guangdong College of Pharmacy) Liu, Wan-Li (Department of Clinical Laboratory, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호

발행연도: 2013.1

수록면: 7,433 - 7,438 (6page)

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Aim: To identify new biomarkers for NPC diagnosis with an anti-EBV Western blot test kit. Methods: Serum samples from 64 NPC patients and healthy subjects with four specific VCA-IgA/EA-IgA profiles were tested with an anti-EBV Western blot test kit from EUROIMMUN AG. Proteins were quantified with scores of intensity visually assigned to the protein bands. The markers which showed statistical differences between the NPC and non-NPC subjects were further evaluated in another 32 NPC patients and 32 controls in comparison with established biomarkers including VCA-IgA, EA-IgA, EBV-related protein IgG, and EBV DNA. Results: Among the markers screened, EA-D p45-IgG showed a statistically significant difference (p < 0.05) between NPC and non-NPC subjects with VCA-IgA positivy. In 32 VCA-IgA positive NPC patients and 32 control subjects, the diagnostic accuracy of EA-D p45-IgG was 78.1% with a positive predictive value of 77.8% and a negative predictive value of 78.6%. In the verification experiment, the specificity and sensitivity of EA-D p45-IgG were 75.0% and 90.6 %, respectively. Conclusions: EA-D p45-IgG might be a potential biomarker for NPC diagnosis, especially among VCA-IgA positive subjects.

#EBV #NPC #Western blot #viral capsid antigen #early antigen #EBV nuclear antigen #diagnosis

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Chen, Hao

소속기관 Department of Clinical Laboratory & Center for Gene Diagnosis, Zhongnan Hospital of Wuhan Univer