Fermented Prunus mume with Probiotics Inhibits 7,12-Dimethylbenz[a]anthracene and 12-O-Tetradecanoyl phorbol-13-acetate Induced Skin Carcinogenesis through Alleviation of Oxidative Stress

Lee, Jin-A; Ko, Jae-Hyung; Jung, Bock-Gie; Kim, Tae-Hoon; Hong, Ji-In; Park, Young-Seok; Lee, Bong-Joo

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자료유형: 학술저널

저자정보: Lee, Jin-A (Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University) Ko, Jae-Hyung (Kyonggido Livestock and Veterinary Service) Jung, Bock-Gie (Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University) Kim, Tae-Hoon (Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University) Hong, Ji-In (Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University) Park, Young-Seok (Department of Companion and Laboratory Animal Science, Kongju National University) Lee, Bong-Joo (Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제5호

발행연도: 2013.1

수록면: 2,973 - 2,978 (6page)

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Maesil (Prunus mume Siebold & Zucc.), a member of the genus Rosaceae, has been reported to have antioxidative effects, as well as anticancer influence in many cancer lines. Thus, this present study was designed to investigate the inhibitory effect of fermented Maesil with probiotics against 7,12-dimethylbenz[a]anthracene (DMBA), 12-O-tetradecanoyl phorbol 13-acetate (TPA)-induced mouse skin carcinogenesis via its antioxidative potential. Mice were fed a diet containing fermented Maesil, containing either 1% (1% FM fed group) or 2% (2% FM fed group) along with probiotics following DMBA and TPA exposure. Continuous ingestion of the experimental feed markedly inhibited skin carcinogenesis, as evidenced by a marked decrease in papilloma numbers and epidermal hyperplasia as well as cellular proliferation and the percentage of proliferating-cell nuclear antigen positive cells. Also, the FM fed group showed an increase of total antioxidant capacity as well as an increased level of phase II detoxifying enzymes such as superoxide dismutase, concurrent with a decreased lipid peroxidation activity level. Taken together, these results suggest that fermented Maesil has the ability to suppress the development of DMBA-TPA induced skin carcinogenesis, via the reduction of lipid peroxidation, enhancing total antioxidant capacity and phase II detoxifying enzyme.

#Prunus mume #maesil #skin cancer #oxidative stress #inhibitory potential

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Lee, Jin-A

소속기관 Department of Veterinary Infectious Disease, College of Veterinary Medicine, Chonnam National Univer