Frequency, Clinical Pattern and Outcome of Thrombosis in Cancer Patients in Saudi Arabia

Aleem, Aamer; Diab, Abdul Rahman Al; Alsaleh, Khalid; Algahtani, Farjah; Alsaeed, Eyad; Iqbal, Zafar; El-Sherkawy, Mohamed Sherif

추천

검색

자료유형: 학술저널

저자정보: Aleem, Aamer (Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University) Diab, Abdul Rahman Al (Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University) Alsaleh, Khalid (Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University) Algahtani, Farjah (Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University) Alsaeed, Eyad (Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid University Hospital, King Saud University) Iqbal, Zafar (Department of Pathology, College of Medicine and King Khalid University Hospital, King Saud University) El-Sherkawy, Mohamed Sherif (Department of Radiology, College of Medicine and King Khalid University Hospital, King Saud University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,311 - 1,315 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Objectives: Thrombotic risk is increased in patients with cancer and there are important implications for those who suffer a venous thromboembolism (VTE). We undertook this study to determine the frequency, clinical patterns, and outcome of VTE in Saudi patients with cancer. Methods: Cancer (solid tumors and lymphoma) patients who developed VTE from January 2004 to January 2009 were studied retrospectively. Demographics and clinical characteristics related to thrombosis and cancer were evaluated. Results: A total of 701 patients with cancer were seen during the study period. VTE was diagnosed in 47 (6.7%) patients (median age 52, range 18-80 years). Lower limb DVT was the most common type, seen in 47% patients, followed by PE in 19%, and 19% patients had both DVT & PE. Thrombosis was symptomatic in 72% patients while it was an incidental finding on routine workup in 28%. Cancer and VTE were diagnosed at the same time in 38% of patients, and 47% patients developed VTE during the course of disease after the cancer diagnosis. The majority of VTE post cancer diagnoses occurred during the first year (median 4 months, range 1-14). Additional risk factors for VTE were present in 22 (47%) patients and 14 (30%) of these patients were receiving chemotherapy at the time of thrombosis. Only 5 (10.6%) patients were receiving thrombo-prophylaxis at the time of VTE diagnosis. Most common types of tumors associated with thrombosis were breast cancer, non-Hodgkin's lymphoma and lung cancer. The majority of the affected patients (79%) had advanced stage of cancer. After a median follow-up of 13 (range 0.5-60) months, 38 (81%) patients had died. There was no difference in the mortality of patients with symptomatic or asymptomatic thrombosis (82% vs 78.6%). Conclusions: Thrombotic complications can develop in a significant number of patients with cancer, and almost half of the patients have additional risk factors for VTE. Thrombosis is usually associated with advanced disease and can be asymptomatic in more than a quarter of cases. Thromboprophylaxis in cancer patients is under-utilized. Community based studies are needed to accurately define the extent of this problem and to develop effective prophylactic strategies.

#Cancer #deep venous thrombosis #pulmonary embolism #VTE #Saudi Arabia

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

이 논문의 저자 정보

Aleem, Aamer

소속기관 Department of Medicine, Division of Hematology/Oncology, College of Medicine and King Khalid Univers