Correlation of Microvessel Density with Nuclear Pleomorphism, Mitotic Count and Vascular Invasion in Breast and Prostate Cancers at Preclinical and Clinical Levels

Muhammadnejad, Samad; Muhammadnejad, Ahad; Haddadi, Mahnaz; Oghabian, Mohammad-Ali; Mohagheghi, Mohammad-Ali; Tirgari, Farrokh; Sadeghi-Fazel, Fariba; Amanpour, Saeid

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자료유형: 학술저널

저자정보: Muhammadnejad, Samad (Cancer Research Centre, Cancer Institute of Iran) Muhammadnejad, Ahad (Cancer Research Centre, Cancer Institute of Iran) Haddadi, Mahnaz (Vali-e-Asr Reproductive Health Research Centre) Oghabian, Mohammad-Ali (Research Center for Molecular and Cellular Imaging) Mohagheghi, Mohammad-Ali (Cancer Research Centre, Cancer Institute of Iran) Tirgari, Farrokh (Department of Pathology, Cancer Institute of Iran, Tehran University of Medical Sciences) Sadeghi-Fazel, Fariba (Razi Vaccine and Serum Research Institute) Amanpour, Saeid (Cancer Research Centre, Cancer Institute of Iran)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제1호

발행연도: 2013.1

수록면: 63 - 68 (6page)

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Background: Tumor angiogenesis correlates with recurrence and appears to be a prognostic factor for both breast and prostate cancers. In the present study, we aimed to investigate the correlation of microvessel density (MVD), a measure of angiogenesis, with nuclear pleomorphism, mitotic count, and vascular invasion in breast and prostate cancers at preclinical and clinical levels. Methods: Samples from xenograft tumors of luminal B breast cancer and prostate adenocarcinoma, established by BT-474 and PC-3 cell lines, respectively, and commensurate human paraffin-embedded blocks were obtained. To determine MVD, specimens were immunostained for CD-34. Nuclear pleomorphism, mitotic count, and vascular invasion were determined using hematoxylin and eosin (H&E)-stained slides. Results: MVD showed significant correlations with nuclear pleomorphism (r=0.68, P=0.03) and vascular invasion (r=0.77, P=0.009) in breast cancer. In prostate cancer, MVD was significantly correlated with nuclear pleomorphism (r=0.75, P=0.013) and mitotic count (r=0.75, P=0.012). In the breast cancer xenograft model, a significant correlation was observed between MVD and vascular invasion (r=0.87, P=0.011). In the prostate cancer xenograft model, MVD was significantly correlated with all three parameters (nuclear pleomorphism, r=0.95, P=0.001; mitotic count, r=0.91, P=0.001; and vascular invasion, r=0.79, P=0.017; respectively). Conclusions: Our results demonstrate that MVD is correlated with nuclear pleomorphism, mitotic count, and vascular invasion at both preclinical and clinical levels. This study therefore supports the predictive value of MVD in breast and prostate cancers.

#Breast adenocarcinoma #prostate adenocarcinoma #microvessel density #mitotic count #vascular invasion

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