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자료유형
학술저널
저자정보
Liu, Hong-Zhou (Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University) Peng, Jie (Department of Stomatology, Zhongnan Hospital of Wuhan University) Zheng, Fang (Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University) Wang, Chun-Hong (Department of Public Health, Wuhan University) Han, Ming-Jun (Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제12호
발행연도
2013.1
수록면
7,215 - 7,219 (5page)

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Background: Variation in metabolic genes is regarded as an important factor in processes leading to cancer. However, the effect of GSTT1 null genotype is divergent in the form of lung cancer. Methods: Studies were conducted at different research databases from 1990 to 2013 and the total odds ratio (OR) and 95% confidence interval (CI) were calculated for lung cancer. Review Manager 5.2 and STATE 12 are employed. Results: Total OR value is calculated from 17 articles with 2,118 cases and 2,915 controls. We discovered no significant increase in lung cancer risk among subjects carrying GSTT1 null genotype [OR = 1.15; 95% CI 0.97-1.36] in this meta-analysis. Conclusion: The GSTT1 deletion polymorphism does not have a significant effect on the susceptibility to lung cancer overall in China.

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