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논문 기본 정보

자료유형
학술저널
저자정보
Koo, So-My (Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine) Uh, Soo-Taek (Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine) Kim, Dong Won (Department of Pathology, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine) Kim, Ki-Up (Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine) Kim, Yang-Ki (Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine)
저널정보
대한결핵 및 호흡기학회 Tuberculosis and Respiratory Diseases 결핵 및 호흡기 질환 제76권 제6호
발행연도
2014.1
수록면
284 - 288 (5page)

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Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies. We believed that there are changes in the p53 expression with transformation from reactive hyperplasia to MM. A 65-year-old male was admitted the hospital because of left pleuritic chest pains in 2004. Chest computed tomography (CT) results showed left pleural effusions with loculation and pleural thickening. Pathologic findings revealed reactive mesothelial hyperplasia. In 2008, the patient again felt left pleuritic chest pains. Chest CT showed progressive thickening of the left pleura. Pathologic diagnosis was atypical mesothelial hyperplasia. In 2011, chest CT showed progressive thickening of his left pleura. He was diagnosed with well-differentiated papillary mesothelioma. Serial change was analyzed by immunohistochemical staining for p53 of pleural tissues. There were no remarkable changes in p53 expressions during the transformation to MM.

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