Red Strain Oryza Sativa-Unpolished Thai Rice Prevents Oxidative Stress and Colorectal Aberrant Crypt Foci Formation in Rats

Tammasakchai, Achiraya; Reungpatthanaphong, Sareeya; Chaiyasut, Chaiyavat; Rattanachitthawat, Sirichet; Suwannalert, Prasit

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자료유형: 학술저널

저자정보: Tammasakchai, Achiraya (Department of Pathobiology, Faculty of Science, Mahidol University) Reungpatthanaphong, Sareeya (Department of Pathobiology, Faculty of Science, Mahidol University) Chaiyasut, Chaiyavat (Faculty of Pharmacy, Chiang Mai University) Rattanachitthawat, Sirichet (Faculty of Agricultural Technology, Burapha University Sakaeo Campus) Suwannalert, Prasit (Department of Pathobiology, Faculty of Science, Mahidol University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 1,929 - 1,933 (5page)

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Oxidative stress has been proposed to be involved in colorectal cancer development. Many dark pigments of plants have potent oxidative stress preventive properties. In this study, unpolished Thai rice was assessed for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. Red strain unpolished Thai rice was also administered to rats exposed to azoxymethane (AOM) for induction of aberrant crypt foci (ACF). Serum malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) were investigated for cellular oxidative stress and serum antioxidants, respectively. Red pigment unpolished Thai rice demonstrated high antioxidant activity and was found to significantly and dose dependently decrease the total density and crypt multiplicity of ACF. Consumption of Thai rice further resulted in high serum antioxidant activity and low MDA cellular oxidative stress. Interestingly, the density of ACF was strongly related to MDA at r = 0.964, while it was inversely related with FRAP antioxidants (r = -0.915, p < 0.001). The results of this study suggest that the consumption of red strain of unpolished Thai rice may exert potentially beneficial effects on colorectal cancer through decrease in the level of oxidative stress.

#Aberrant crypt foci #colorectal cancer #oxidative stress #unpolished Thai rice #Thailand

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