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논문 기본 정보

자료유형
학술저널
저자정보
Li, Gang (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) Chang, Hong (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) Zhai, Yun-Peng (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University) Xu, Wei (Department of General Surgery, Provincial Hospital Afficiated to Shandong University, Shandong University)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제9호
발행연도
2013.1
수록면
4,943 - 4,952 (10page)

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Hepatocellular carcinoma (HCC) is one of the most common malignancies, with a very poor prognosis. Despite significant improvements in diagnosis and treatment in recent years, the long-term therapeutic efficacy is poor, partially due to tumor metastasis, tecurrence, and resistance to chemo-or radio-therapy. Recently, it was found that a major feature of tumors is a combination of unrestrained cell proliferation and impaired apoptosis. There are now 8 recogized members of the IAP-family: NAIP, c-IAP1, c-IAP2, XIAP, Survivin, Bruce, Livin and ILP-2. There proteins all contribute to ingibition of apoptosis, and provide new potential avenues of cancer treatment. As a powerful tool to suppress gene expression in mammalian cells, RNAi species for inhibiting IAP genes cab be directed against cancers. This review will provide a brief introduction to recent developments of the application IAP-siRNA in tumor studies, with the aim of inspiring future treatment of HCC.

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