Brain Metastases from Cholangiocarcinoma: a First Case Series in Thailand

Chindaprasirt, Jarin; Sookprasert, Aumkhae; Sawanyawisuth, Kittisak; Limpawattana, Panita; Tiamkao, Somsak

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자료유형: 학술저널

저자정보: Chindaprasirt, Jarin (Medical Oncology Division, Department of Medicine, Facult of Medicine, Khon Kaen University) Sookprasert, Aumkhae (Medical Oncology Division, Department of Medicine, Facult of Medicine, Khon Kaen University) Sawanyawisuth, Kittisak (Ambulatory Medicine Division, Department of Medicine, Facult of Medicine, Khon Kaen University) Limpawattana, Panita (Ambulatory Medicine Division, Department of Medicine, Facult of Medicine, Khon Kaen University) Tiamkao, Somsak (Neurology Division, Department of Medicine, Facult of Medicine, Khon Kaen University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 1,995 - 1,997 (3page)

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Background: Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. Methods: Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. Results: The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. Conclusion: This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.

#Bile duct neoplasm #brain metastasis #cholangiocarcinoma #Thailand

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Chindaprasirt, Jarin

소속기관 Division of Medical Oncology, Internal Medicine Department, Faculty of Medicine, Khon Kaen Universit