Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Patel, Jayendra B.; Patel, Kinjal D.; Patel, Shruti R.; Shah, Franky D.; Shukla, Shilin N.; Patel, Prabhudas S.

추천

검색

자료유형: 학술저널

저자정보: Patel, Jayendra B. (Biochemistry Research Division, The Gujarat Cancer & Research Institute) Patel, Kinjal D. (Biochemistry Research Division, The Gujarat Cancer & Research Institute) Patel, Shruti R. (Biochemistry Research Division, The Gujarat Cancer & Research Institute) Shah, Franky D. (Biochemistry Research Division, The Gujarat Cancer & Research Institute) Shukla, Shilin N. (The Gujarat Cancer & Research Institute) Patel, Prabhudas S. (Biochemistry Research Division, The Gujarat Cancer & Research Institute)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 1,727 - 1,735 (9page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Regardless of advances in treatment modalities with the invention of newer therapies, breast cancer remains a major health problem with respect to its diagnosis, treatment and management. This female malignancy with its tremendous heterogeneous nature is linked to high incidence and mortality rates, especially in developing region of the world. It is the malignancy composed of distinct biological subtypes with diverse clinical, pathological, molecular and genetic features as well as different therapeutic responsiveness and outcomes. This inconsistency can be partially overcome by finding novel molecular markers with biological significance. In recent years, newer technologies help us to indentify distinct biomarkers and increase our understanding of the molecular basis of breast cancer. However, certain issues need to be resolved that limit the application of gene expression profiling to current clinical practice. Despite the complex nature of gene expression patterns of cDNAs in microarrays, there are some innovative regulatory molecules and functional pathways that allow us to predict breast cancer behavior in the clinic and provide new targets for breast cancer treatment. This review describes the landscape of different molecular markers with particular spotlight on vitamin D signaling pathway and apoptotic specific protein of p53 (ASPP) family members in breast cancer.

#Breast cancer #molecular biomarkers #Vitamin D signaling pathway #apoptotic specific protein of p53

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요