HMGB1 Promotes the Synthesis of Pro-IL-1β and Pro-IL-18 by Activation of p38 MAPK and NF-κB Through Receptors for Advanced Glycation End-products in Macrophages

He, Qiang; You, Hong; Li, Xin-Min; Liu, Tian-Hui; Wang, Ping; Wang, Bao-En

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자료유형: 학술저널

저자정보: He, Qiang (Institute of Integrated Traditional Medicine and Western Medicine, Beijing Friendship Hospital, Capital Medical University) You, Hong (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) Li, Xin-Min (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) Liu, Tian-Hui (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) Wang, Ping (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) Wang, Bao-En (Institute of Integrated Traditional Medicine and Western Medicine, Beijing Friendship Hospital, Capital Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제4호

발행연도: 2012.1

수록면: 1,365 - 1,370 (6page)

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The high mobility group box-1 (HMGB1) protein and NALP3 inflammasome have been identified to play important roles in inflammation and cancer pathogenesis, but the relationships between the two and cancer remain unclear. The current study investigated the relationship between HMGB1 and the NALP3 inflammasome in THP-1 macrophages. HMGB1 was found unable to activate the NALP3 inflammasome and failed to induce the release of the IL-$1{\beta}$ and IL-18 in THP-1 macrophages. HMGB1 was also found significantly enhanced the activity of ATP to induce IL-$1{\beta}$ and IL-18 by the induction of increased expression of pro-IL-$1{\beta}$ and pro-IL-18. This process was dependent on activation of RAGE, MAPK p38 and NF-${\kappa}B$ signaling pathway. These results demonstrate that HMGB1 promotes the synthesis of pro-IL-$1{\beta}$ and pro-IL-18 in THP-1 macrophages by the activation of p38 MAPK and NF-${\kappa}B$ through RAGE. HMGB1 likely plays an important role in the first step of the release of the IL-$1{\beta}$ and IL-18, preparing for other cytokines to induce excessive release of IL-$1{\beta}$ and IL-18 which promote inflammation and cancer progression.

#High mobility group box1 #NALP3 inflammasome #inflammation #cancer

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He, Qiang

소속기관 Institute of Integrated Traditional Medicine and Western Medicine, Beijing Friendship Hospital, Capi