Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma

Doroudchi, Mehrnoosh; Pishe, Zahra Ghanaat; Malekzadeh, Mahyar; Golmoghaddam, Hossein; Taghipour, Mousa; Ghaderi, Abbas

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자료유형: 학술저널

저자정보: Doroudchi, Mehrnoosh (Department of Immunology, School of Medicine, Shiraz University of Medical Sciences) Pishe, Zahra Ghanaat (Shiraz University of Medical Sciences) Malekzadeh, Mahyar (Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences) Golmoghaddam, Hossein (Department of Immunology, School of Medicine, Shiraz University of Medical Sciences) Taghipour, Mousa (Shiraz University of Medical Sciences) Ghaderi, Abbas (Department of Immunology, School of Medicine, Shiraz University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제14권 제9호

발행연도: 2013.1

수록면: 5,225 - 5,230 (6page)

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Background: There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours. We aimed to compare the levels of IL-17A and IL-6 in sera of glioma, meningioma and schwannoma patients as well as in healthy individuals. Materials and Methods: IL-17A and IL-6 levels were measured in sera of 38 glioma, 24 meningioma and 18 schwannoma patients for comparison with 26 healthy controls by commercial ELISA assays. Results: We observed an increase in the IL-17A in 30% of glioma patients while only 4% and 5.5% of meningioma and schwannoma patients and none of the healthy controls showed elevated IL-17A in their sera ($0.29{\pm}0.54$, $0.03{\pm}0.15$ and $0.16{\pm}0.68$ vs. $0.00{\pm}0.00pg/ml$; p=0.01, p=0.01 and p=0.001, respectively). There was also a significant decrease in the level of IL-6 in glioma patients compared to healthy controls ($2.34{\pm}4.35$ vs. $4.67{\pm}4.32pg/ml$; p=0.01). There was a direct correlation between the level of IL-17A and age in glioma patients (p=0.005). Glioma patients over 30 years of age had higher IL-17A and lower IL-6 in their sera compared to the young patients. In addition, a non-significant grade-specific inverse trend between IL-17A and IL-6 was observed in glioma patients, where high-grade gliomas had higher IL-17A and lower IL-6. Conclusions: Our data suggest a Th17 mediated inflammatory response in the pathogenesis of glioma. Moreover, tuning of IL-6 and IL-17A inflammatory cytokines occurs during progression of glioma. IL-17A may be a potential biomarker and/or immunotherapeutic target in glioma cases.

#Glioma #meningioma #schwannoma #IL-17A #IL-6 #serum

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