Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Pruegsanusak, Kowit; Peeravut, Sumet; Leelamanit, Vitoon; Sinkijcharoenchai, Wattana; Jongsatitpaiboon, Jaturong; Phungrassami, Temsak; Chuchart, Kanyarat; Thongsuksai, Paramee

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저자정보: Pruegsanusak, Kowit (Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University) Peeravut, Sumet (Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University) Leelamanit, Vitoon (Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University) Sinkijcharoenchai, Wattana (Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University) Jongsatitpaiboon, Jaturong (Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University) Phungrassami, Temsak (Department of Radiology, Faculty of Medicine, Prince of Songkla University) Chuchart, Kanyarat (Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University) Thongsuksai, Paramee (Department of Pathology, Faculty of Medicine, Prince of Songkla University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제3호

발행연도: 2012.1

수록면: 885 - 890 (6page)

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Background: Head and neck cancers are prevalent in Thailand, in particular in the southern region of the country. However, survival with a large data set has not been reported. The purpose of the present study was to evaluate the survival figures and the prognostic factors in a cohort of patients treated in a university hospital located in the south of Thailand. Patients and Methods: Consecutive new cases of primary carcinoma of the oral cavity, oropharyx, hypopharynx and larynx, treated at Songklanagarind Hospital during 2002 to 2004, were analyzed. The 5-year overall survival rates were obtained by the Kaplan-Meier method. Prognostic factors were identified through multivariate Cox regression analysis. Results: A total 1,186 cases were analyzed. Two-thirds (66.6%) of the cases were at advanced stage (stage III & IV) at presentation. The five-year overall survivals for the whole cohort, oral cavity, oropharynx, hypopharynx and larynx were 24.1%, 25.91%, 19.2%, 13.4%, 38.0% respectively. Stage and treatment type were strong prognostic factors for all sites. An age ${\geq}$ 80 years was associated with poor survival in oral cavity and larynx cancer. Conclusions: The results revealed remarkably poor outcomes of the patients in the series, indicating a strong need to increase the proportion of early stage presentations and maximize the treatment efficacy to improving outcomes. Very old patients are of particular concern for treatment care of oral cavity and larynx cancer.

#Head and neck cancer #upper aerodigestive tract #cancer #survival #prognosis #Thailand

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Pruegsanusak, Kowit

소속기관 Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla Univ