Treatment Outcomes of Epithelial Ovarian Cancers Following Maximum Cytoreduction and Adjuvant Paclitaxel-Carboplatin Chemotherapy: Egyptian NCI Experience

Nassar, Hanan Ramadan; Zeeneldin, Ahmed A; Helal, Amany Mohamed; Ismail, Yahia Mahmoud; Elsayed, Abeer Mohamed; Elbassuiony, Mohamed A; Moneer, Manar M

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저자정보: Nassar, Hanan Ramadan (Medical Oncology Department, NCI, Cairo University) Zeeneldin, Ahmed A (Medical Oncology Department, NCI, Cairo University) Helal, Amany Mohamed (Medical Oncology Department, NCI, Cairo University) Ismail, Yahia Mahmoud (Medical Oncology Department, NCI, Cairo University) Elsayed, Abeer Mohamed (Pathology Department, NCI, Cairo University) Elbassuiony, Mohamed A (Medical Oncology Department, NCI, Cairo University) Moneer, Manar M (Statistical Department, NCI, Cairo University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제16호

발행연도: 2015.1

수록면: 7,237 - 7,242 (6page)

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Background: Epithelial ovarian cancer (EOC) is the commonest malignancy involving the ovaries. Maximum surgical cytoreduction (MCR) followed by adjuvant taxane-platinum chemotherapy are the standard of care treatments. Aims: To study treatment outcomes of EOC patients that were maximally cyto-reduced and received adjuvant paclitaxel-carboplatin (PC) chemotherapy. Materials and Methods: This retrospective cohort study included 174 patients with EOC treated at the Egyptian National Cancer Institute between 2006 and 2010. For inclusion, they should have had undergone MCR with no-gross residual followed by adjuvant PC chemotherapy. MCR was total abdominal hysterectomy/bilateral salpingo-oophorectomy [TAH/BSO] or unilateral salpingo-oophorectomy [USO] plus comprehensive staging. Results: The median age was 50 years. Most patients were married (97.1%), had offspring (92.5%), were postmenopausal (53.4%), presented with abdominal/pelvic pain and swelling (93.7%), had tumors involving both ovaries (45.4%) without extra-ovarian extension i.e. stage I (55.2%) of serous histology (79.9%) and grade II (87.4%). TAH/BSO was performed in 97.7% of cases. A total of 1,014 PC chemotherapy cycles were administered and were generally tolerable with 93.7% completing 6 cycles. Alopecia and numbness were the commonest adverse events. The median follow up period was 42 months. The 2-year rates for disease free survival (DFS) and overall survival (OS) were 70.7% and 94.8%, respectively. The respective 5-year rates were 52.6% and 81.3%. Advanced stage and high-grade were significantly associated with poor DFS and OS (p<0.001). Age >65 years was associated with poor OS (p =0.008). Using Cox-regression, stage was independent predictor of poor DFS and OS. Age was an independent predictor of poor OS.

#Ovarian neoplasms #epithelial #Egypt, National Cancer Institute #cytoreduction #adjuvant chemotherapy

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