Evaluation of the Geometric Accuracy of Anatomic Landmarks as Surrogates for Intrapulmonary Tumors in Image-guided Radiotherapy

Li, Hong-Sheng; Kong, Ling-Ling; Zhang, Jian; Li, Bao-Sheng; Chen, Jin-Hu; Zhu, Jian; Liu, Tong-Hai; Yin, Yong

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자료유형: 학술저널

저자정보: Li, Hong-Sheng (Department of Radiation Oncology, Cancer Hospital and Institute, Tianjin Medical University) Kong, Ling-Ling (Department of Radiation Oncology [Chest Section], Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute) Zhang, Jian (Department of Radiation Oncology, Cancer Hospital and Institute, Tianjin Medical University) Li, Bao-Sheng (Department of Radiation Oncology [Chest Section], Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute) Chen, Jin-Hu (Department of Radiation Physics, Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute) Zhu, Jian (Department of Radiation Physics, Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute) Liu, Tong-Hai (Department of Radiation Physics, Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute) Yin, Yong (Department of Radiation Physics, Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospi)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제5호

발행연도: 2012.1

수록면: 2,393 - 2,398 (6page)

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Objectives: The purpose of this study was to evaluate the geometric accuracy of thoracic anatomic landmarks as target surrogates of intrapulmonary tumors for manual rigid registration during image-guided radiotherapy (IGRT). Methods: Kilovolt cone-beam computed tomography (CBCT) images acquired during IGRT for 29 lung cancer patients with 33 tumors, including 16 central and 17 peripheral lesions, were analyzed. We selected the "vertebrae", "carina", and "large bronchi" as the candidate surrogates for central targets, and the "vertebrae", "carina", and "ribs" as the candidate surrogates for peripheral lesions. Three to six pairs of small identifiable markers were noted in the tumors for the planning CT and Day 1 CBCT. The accuracy of the candidate surrogates was evaluated by comparing the distances of the corresponding markers after manual rigid matching based on the "tumor" and a particular surrogate. Differences between the surrogates were assessed using 1-way analysis of variance and post hoc least-significant-difference tests. Results: For central targets, the residual errors increased in the following ascending order: "tumor", "bronchi", "carina", and "vertebrae" there was a significant difference between "tumor" and "vertebrae" (p = 0.010). For peripheral diseases, the residual errors increased in the following ascending order: "tumor", "rib", "vertebrae", and "carina" There was a significant difference between "tumor" and "carina" (p = 0.005). Conclusions: The "bronchi" and "carina" are the optimal surrogates for central lung targets, while "rib" and "vertebrae" are the optimal surrogates for peripheral lung targets for manual matching of online and planned tumors.

#Cone-beam CT #image-guided radiotherapy #lung cancer #image registration #manual matching

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Li, Hong-Sheng

소속기관 Department of Radiation Oncology, Cancer Hospital and Institute, Tianjin Medical University