지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호
- 발행연도
- 2016.1
- 수록면
- 3,329 - 3,334 (6page)
이용수
초록· 키워드
오류제보하기
Cancer is thought to be a direct result of transcriptional misregulation. Broad analysis of transcriptional regulatory elements in healthy and cancer cells is needed to understand cancer development. Nucleases regulatory domains are recruited to bind and manipulate a specific genomic locus with high efficacy and specificity. TALENs (transcription activator-like effector nuclease) fused to endonuclease FokI have been used widely to target specific sequences to edit several genes in healthy and cancer cells. This approach is promising to target specific cancer genes and for this purpose it is needed to pack such TALENs into viral vectors. There are some considerations which control the success of this approach, targeting appropriate sequences with efficient construction of TALENs being crucial factors. We face some obstacles in construction of TALENs; in this study we made a modification to the method of Cermk et al 2011 and added one step to make it easier and increase the availability of constructs.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Generation of interleukin 2 receptor gamma (IL2Rg) knockout rats with TALEN-mediated gene targeting
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Comparison for the tumorigenic phenotypes between FVB/N-Trp53tm1Hw1 and C57BL/6N Trp53tm1Hw1 with TALEN-mediated p53 mutant gene
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Engineered nuclease-mediated generation of knockout mouse models of cyclin-dependent kinase inhibitors
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing
한국실험동물학회 학술발표대회 논문집
2020 .02
-
How Can We Treat Cancer Disease Not Cancer Cells?
Cancer Research and Treatment
2017 .01
-
Production of α 1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology
Journal of Veterinary Science
2016 .03
-
Protection and Functional Melioration of Myocardial Infarction by Stem Cells Safe-harboring Inducible Vegf Gene
한국실험동물학회 학술발표대회 논문집
2015 .08
-
암 치료성적 향상을 위한 제안
대한의사협회지
2017 .01
-
유방암 줄기세포 개념 및 제한점
의생명과학
2018 .01
-
Cancer Metabolism: Strategic Diversion from Targeting Cancer Drivers to Targeting Cancer Suppliers
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Prediction of Cancer Incidence and Mortality in Korea, 2020
Cancer Research and Treatment
2020 .01
-
Phenotyping analysis of p53-mutant mice produced by TALEN-mediated gene inactivation and comparison with homologous recombination-mediated p53-mutant mice
한국실험동물학회 학술발표대회 논문집
2017 .02
-
Prediction of Cancer Incidence and Mortality in Korea, 2023
Cancer Research and Treatment
2023 .04
-
Prediction of Cancer Incidence and Mortality in Korea, 2022
Cancer Research and Treatment
2022 .04
-
Prediction of Cancer Incidence and Mortality in Korea, 2021
Cancer Research and Treatment
2021 .01
-
암세포 대사의 이해와 갑상선암
International Journal of Thyroidology
2015 .01
-
National Cancer Control Plan of the Korea: Current Status and the Fourth Plan (2021-2025)
예방의학회지
2023 .05
-
Prediction of Cancer Incidence and Mortality in Korea, 2019
Cancer Research and Treatment
2019 .01
-
Cancer Genomics
대한외과학회 학술대회 초록집
2018 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0