Distinctions Between Clinicopathological Factors and Prognosis of Alpha-fetoprotein Negative and Positive Hepatocelluar Carcinoma Patients

Xu, Jia; Liu, Chang; Zhou, Lei; Tian, Feng; Tai, Ming-Hui; Wei, Ji-Chao; Qu, Kai; Meng, Fan-Di; Zhang, Ling-Qiang; Wang, Zhi-Xin; Zhang, Jing-Yao; Chang, Hu-Lin; Liu, Si-Nan; Xu, Xin-Shen; Song, Yan-Zhou; Liu, Jun; Zhang, Peng

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자료유형: 학술저널

저자정보: Xu, Jia (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Liu, Chang (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Zhou, Lei (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Tian, Feng (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Tai, Ming-Hui (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Wei, Ji-Chao (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Qu, Kai (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Meng, Fan-Di (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical College, Xi'an Jiaotong University) Zhang, Ling-Qiang (Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical Co) Wang, Zhi-Xin Zhang, Jing-Yao Chang, Hu-Lin Liu, Si-Nan Xu, Xin-Shen Song, Yan-Zhou Liu, Jun Zhang, Peng

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제2호

발행연도: 2012.1

수록면: 559 - 562 (4page)

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Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.

#Clinicopathological factors #prognosis #alpha-fetoprotein status #hepatocellular carcinoma

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Xu, Jia

소속기관 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaoton