Molecular and Circulatory Expression of Insulin Growth Factors in Indian Females with Advanced Cervical Cancer

Sharma, Manoj; Satyam, Abhigyan; Abhishek, Ashu; Khan, Rehan; Rajappa, Medha; Sharma, Alpana

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저자정보: Sharma, Manoj (Department of Radiotherapy, Maulana Azad Medical College and Associated Lok Nayak Hospital) Satyam, Abhigyan (Department of Biochemistry, All India Institute of Medical Sciences) Abhishek, Ashu (Department of Radiotherapy, Maulana Azad Medical College and Associated Lok Nayak Hospital) Khan, Rehan (Department of Biochemistry, All India Institute of Medical Sciences) Rajappa, Medha (Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research) Sharma, Alpana (Department of Biochemistry, All India Institute of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제12호

발행연도: 2012.1

수록면: 6,475 - 6,479 (5page)

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Background: Recent studies have demonstrated an association between insulin growth factor (IGF) and insulin growth factor binding protein-3 (IGFBP-III) serum levels and increased risk for various cancers. However, little information is available on clinical implications of the IGF system in Indian patients with cervical cancer. This study explored associations by analyzing their expression profiles in cervical cancer cases. Materials and Methods: Totals of 50 patients with advanced cervical cancer and 40 healthy controls were enrolled. Human papillomavirus (HPV) and cervical biopsy sample were obtained from all participating women. Circulatory levels were estimated by ELISA and the tissue expression was assessed using RT-PCR and Western blotting. Results: Levels of IGF-I and II showed significant increase whereas IGFBP-III showed significant decline in all patients as compared to controls. Spearman correlation analysis between IGFs and HPV status showed significant correlations. Conclusions: We demonstrated elevated circulating levels and tissue expression of IGF-I and IGF-II in advancer cancer cervix patients, as compared with controls, with a converse trend being apparent for IGFBP-III. In future, associations of the IGF system and clinical outcome of cervical cancer patients in post treatment samples might point to significance in disease mapping as a prognostic marker after validation with a larger patient series.

#Insulin growth factors #insulin growth factor binding protein #cervical cancer #human papilloma virus

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