Association of TNF-α-308 and -238 Polymorphisms with Risk of Cervical Cancer: A Meta-analysis

Pan, Feng; Tian, Jing; Ji, Chu-Shu; He, Yi-Fu; Han, Xing-Hua; Wang, Yong; Du, Jian-Ping; Jiang, Feng-Shou; Zhang, Ying; Pan, Yue-Yin; Hu, Bing

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자료유형: 학술저널

저자정보: Pan, Feng (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) Tian, Jing (Menzies Research Institute, University of Tasmania) Ji, Chu-Shu (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) He, Yi-Fu (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) Han, Xing-Hua (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) Wang, Yong (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) Du, Jian-Ping (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) Jiang, Feng-Shou (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University) Zhang, Ying (Department of Geriatrics, the Third Affiliated Hospital of Anhui Medical University) Pan, Yue-Yin (Department of Oncology, the First Affiliated Hospital of Anhui Medical University Hefei) Hu, Bing (Department of Oncology, Anhui Provincial Hospital affiliated to Anhui Medical University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제13권 제11호

발행연도: 2012.1

수록면: 5,777 - 5,783 (7page)

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Published data on the associations between tumor necrosis factor-alpha (TNF-${\alpha}$) promoter -308G>A and -238G>A polymorphisms and cervical cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Data were collected from MEDLINE and PubMed databases. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated in a fixed/random effect model. 13 separate studies including 3294 cases and 3468 controls were involved in the meta-analysis. We found no association between TNF-${\alpha}$-308G>A polymorphism and cervical cancer in overall population. In subgroup analysis, significantly elevated risks were found in Caucasian population (A vs. G: OR = 1.43, 95% CI = 1.00-2.03; AA vs. GG: OR = 2.09, 95% CI = 1.34-3.25; Recessive model: OR = 2.09, 95% CI = 1.35-3.25) and African population (GA vs. GG: OR = 1.53, 95% CI = 1.02-2.30). An association of TNF-${\alpha}$-238G>A polymorphism with cervical cancer was found (A vs. G: OR = 0.61, 95% CI = 0.47-0.78; GA vs. GG: OR = 0.59, 95% CI = 0.45-0.77; Dominant model: OR = 0.59, 95% CI = 0.46-0.77). When stratified by ethnicity, similar association was observed in Caucasian population (A vs. G: OR = 0.62, 95% CI = 0.46-0.84; GA vs. GG: OR = 0.59, 95% CI = 0.43-0.82; Dominant model: OR = 0.60, 95% CI = 0.44-0.83). In summary, this meta-analysis suggests that TNF-${\alpha}$-238A allele significantly decreased the cervical cancer risk, and the TNF-${\alpha}$-308G>A polymorphism is associated with the susceptibility to cervical cancer in Caucasian and African population.

#Cervical cancer #genetic polymorphisms #TNF- ${alpha}$ #susceptibility #meta-analysis

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